Fungicidal compositions

ABSTRACT

A composition suitable for control of diseases caused by phytopathogens comprising a mixture of a compound of formula I 
     
       
         
         
             
             
         
       
     
     with two compounds selected from compounds known for their fungicidal activity; and a method of controlling diseases on useful plants.

RELATED APPLICATION INFORMATION

This application is a continuation of U.S. patent application Ser. No.14/416,775 filed on 23 Jan. 2015 which is a 371 of InternationalApplication No. PCT/EP2013/065480, filed 23 Jul. 2013, which claimspriority to 12177995.3, filed 26 Jul. 2012, the contents of which areincorporated herein by reference herein.

The present invention relates to novel fungicidal compositions for thetreatment of phytopatho-genic diseases of useful plants, especiallyphytopathogenic fungi, and to a method of controlling phytopathogenicdiseases on useful plants.

It is known from WO2008/148570, WO 2010/063700, WO 2010/084078 and WO2008/151828 that certain pyrazolyl-carboxamide derivatives havebiological activity against phytopathogenic fungi. On the other handvarious fungicidal compounds of different chemical classes are widelyknown as plant fungicides for application in various crops of cultivatedplants. However, crop tolerance and activity against phytopathogenicplant fungi do not always satisfy the needs of agricultural practice inmany incidents and aspects. In order to overcome this problem, binarymixtures of pyrazolyl-carboxamides with certain fungicides have beenprovided in WO 2012/041874.

It has now been found that the addition of a specific further fungicideto compositions comprising the binary mixtures disclosed in WO2012/041874 leads to novel ternary fungicidal compositions withadvantageous properties.

There is therefore proposed in accordance with the invention a novelcomposition suitable for the control of diseases caused byphytopathogens comprising as component (A) a compound of formula I

wherein

R is hydrogen or methoxy;

Q is

wherein

R₁ is hydrogen, halogen or C₁-C₆alkyl;

R₂ is hydrogen, halogen, C₁-C₆alkyl, C₂-C₆alkenyl, C₃-C₆alkinyl,C₃-C₆cycloalkyl-C₃-C₆alkinyl, halophenoxy, halophenyl-C₃-C₆alkinyl,C(C₁-C₄alkyl)═NO—C₁-C₄alkyl, C₁-C₆haloalkyl, C₁-C₆haloalkoxy,C₂-C₆haloalkenyl, or C₂-C₆haloalkenyloxy;

R₃ is hydrogen, halogen or C₁-C₆alkyl; with the proviso that at leastone of R₁, R₂ and R₃ is different from hydrogen;

R₄, R₅ and R₆, independently from each other, are hydrogen, halogen or≡R₇; with the proviso that at least one of R₄, R₅ and R₆ is differentfrom hydrogen;

R₇ is hydrogen, C₁-C₆alkyl, C₁-C₆haloalkyl or C₁-C₄alkoxyalkyl; and

R₈ is hydrogen or methoxy;

and agrochemically acceptable salts, stereoisomers, diastereoisomers,enantiomers and tautomers of those compounds;

and

as component (B) a compound selected from the group consisting ofazoxystrobin (47), dimoxystrobin (226), fluoxastrobin (382),kresoxim-methyl (485), metominostrobin (551), orysastrobin,picoxystrobin (647), pyraclostrobin (690), trifloxystrobin (832), acompound of formula B-1.1

azaconazole (40), bromuconazole (96), cyproconazole (207),difenoconazole (247), diniconazole (267), diniconazole-M (267),epoxiconazole (298), fenbuconazole (329), fluquinconazole (385),flusilazole (393), flutriafol (397), hexaconazole (435), imazalil (449),imibenconazole (457), ipconazole (468), metconazole (525), myclobutanil(564), oxpoconazole (607), pefurazoate (618), penconazole (619),prochloraz (659), propiconazole (675), prothioconazole (685),simeconazole (731), tebuconazole (761), tetraconazole (778), triadimefon(814), triadimenol (815), triflumizole (834), triticonazole (842),diclobutrazol (1068), etaconazole (1129), furconazole (1198),furconazole-cis (1199) and quinconazole (1378); aldimorph (CAS Reg. No.91315-15-0), dodemorph (288), fenpropimorph (344), tridemorph (830),fenpropidin (343), spiroxamine (740), piperalin (648), a compound offormula B-3.1

cyprodinil (208), mepanipyrim (508), pyrimethanil (705), anilazine(878), benalaxyl (56), benalaxyl-M, benodanil (896), benomyl (62),benthiavalicarb, benthiavalicarb-isopropyl (68), biphenyl (81),bitertanol (84), blasticidin-S (85), bordeaux mixture (87), boscalid(88), bupirimate (98), cadmium chloride, captafol (113), captan (114),carbendazim (116), carbon disulfide (945), carboxin (120), carpropamid(122), cedar leaf oil, chinomethionat (126), chloroneb (139),chlorothalonil (142), chlozolinate (149), cinnamaldehyde, copper, copperammoniumcarbonate, copper hydroxide (169), copper octanoate (170),copper oleate, copper sulphate (87), cyazofamid (185), cycloheximide(1022), cymoxanil (200), dichlofluanid (230), dichlone (1052),dichloropropene (233), diclocymet (237), diclomezine (239), dicloran(240), diethofencarb (245), diflumetorim (253), dimethirimol (1082),dimethomorph (263), dinocap (270), dithianon (279), dodine (289),edifenphos (290), ethaboxam (304), ethirimol (1133), etridiazole (321),famoxadone (322), fenamidone (325), fenaminosulf (1144), fenamiphos(326), fenarimol (327), fenfuram (333), fenhexamid (334), fenoxanil(338), fenpiclonil (341), fentin acetate (347), fentin chloride, fentinhydroxide (347), ferbam (350), ferimzone (351), fluazinam (363),fludioxonil (368), flusulfamide (394), flutolanil (396), folpet (400),formaldehyde (404), fosetyl-aluminium (407), fthalide (643),fuberidazole (419), furalaxyl (410), furametpyr (411), flyodin (1205),fuazatine (422), hexachlorobenzene (434), hymexazole, iminoctadinetris(albesliate) (CAS Reg. No: 99257-43-9), iodocarb (3-Iodo-2-propynylbutyl carbamate), iprobenfos (IBP) (469), iprodione (470), iprovalicarb(471), isoprothiolane (474), kasugamycin (483), mancozeb (496), maneb(497), manganous dimethyldithiocarbamate, mefenoxam (Metalaxyl-M) (517),mepronil (510), mercuric chloride (511), mercury, metalaxyl (516),methasulfocarb (528), metiram (546), metrafenone, nabam (566), neem oil(hydrophobic extract), nuarimol (587), octhilinone (590), ofurace (592),oxadixyl (601), oxine copper (605), oxolinic acid (606), oxycarboxin(608), oxytetracycline (611), paclobutrazole (612), paraffin oil (628),paraformaldehyde, pencycuron (620), pentachloronitrobenzene (716),pentachlorophenol (623), penthiopyrad, perfurazoate, phosphoric acid,polyoxin (654), polyoxin D zinc salt (654), potassium bicarbonate,probenazole (658), procymidone (660), propamocarb (668), propineb (676),proquinazid (682), prothiocarb (1361), pyrazophos (693), pyrifenox(703), pyroquilon (710), quinoxyfen (715), quintozene (PCN(B) (716),silthiofam (729), sodium bicarbonate, sodium diacetate, sodiumpropionate, streptomycin (744), sulphur (754), TCMTB, tecloftalam,tecnazene (TCN(B) (767), thiabendazole (790), thifluzamide (796),thiophanate (1435), thiophanate-methyl (802), thiram (804),tolclofos-methyl (808), tolylfluanid (810), triazoxide (821),trichoderma harzianum (825), tricyclazole (828), triforine (838),triphenyltin hydroxide (347), validamycin (846), vinclozolin (849),zineb (855), ziram (856), zoxamide (857),1,1-bis(4-chlorophenyl)-2-ethoxyethanol (IUPAC-Name) (910),2,4-dichlorophenyl benzenesulfonate (IUPAC-/Chemical Abstracts-Name)(1059), 2-fluoro-N-methyl-N-1-naphthylacetamide (IUPAC-Name) (1295),4-chlorophenyl phenyl sulfone (IUPAC-Name) (981), a compound of formulaB-5.1

a compound of formula B-5.2

a compound of formula B-5.3

a compound of formula B-5.4

a compound of formula B-5.5

a compound of formula B-5.6

a compound of formula B-5.7

3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid(2-bicyclopropyl-2-yl-phenyl)-amide (compound B-5.8),3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid(9-isopropyp-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide(compound B-5.9), 1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxylic acid[2-(1,3-dimethylbutyl)phenyl]-amide (compound B-5.10),3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid(3′,4′-dichloro-5-fluoro-1,1′-biphenyl-2-yl)-amide (compound B-5.11,bixafen),N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamid(compound B-5.12, fluopyram),3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acidN-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-amide (compound B-5.13),3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acidN-[2-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-amide (compound B-5.14),3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acidN-[2-(2-chloro-1,1,2-trifluoroethoxy)phenyl]-amide (compound B-5.15),3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acidN-(4′-trifluoromethyl-biphen-2-yl)-amide (compound B-5.16),3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acidN-(2′-trifluoromethyl-biphen-2-yl)-amide (compound B-5.17) and3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acidN-(2′-trifluoromethyl-biphen-2-yl)-amide (compound B-5.18),acibenzolar-S-methyl (6), chlormequat chloride (137), ethephon (307),mepiquat chloride (509) and trinexapac-ethyl (841), abamectin (1),clothianidin (165), emamectin benzoate (291), imidacloprid (458),tefluthrin (769), thiamethoxam (792), glyphosate (419), a compound offormula V

fomesafen, isopyrazam, sedaxane, the compound of formula (VI)

the compound of formula (VII)

1-[4-[4-[(5S)5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone,1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone,fluxapyroxad, phosphorous acid, phosphorous acid sodium salt andphosphorous acid ammonium salt;

and as component (C) a compound selected from the group consisting ofthe compound of formula VII, fluxapyroxad, bixafen, penthiopyrad,fluopyram, boscalid, isopyrazam, propiconazole, cyproconazole,difenoconazole, prothioconazole, thiabendazole azoxystrobin, thiophanatemethyl, iminoctadine tris(albesilate), tebuconazole, pyraclostrobin,trifloxystrobin, fludioxonil, cyprodinil and fluazinam; with theexception of the mixtures comprising a compound of formulaI+azoxystrobin+cyproconazole and with the proviso that in eachcomposition component (B) is different from component (C).

According to the present invention, preferred salts of glyphosate arethe potassium, isopropylammonium, sodium, trimesium, ammonium anddiammonium salts. Preferred salts of glufosinate are disclosed in U.S.Pat. No. 4,168,963, a preferred salt is the ammonium salt.

The compounds of formula I wherein R₈ is hydrogen can occur in the twoenantiomeric forms of formula Ia and Ib:

The invention encompasses both enantiomeric forms of the compounds offormula I. The compounds of formula I and their preparation aredescribed in WO 2010/063700, WO 2010/084078 and WO 2008/151828.

It has been found that the use of components (B) and (C) in combinationwith component (A) surprisingly and substantially may enhance theeffectiveness of the latter against fungi, and vice versa. Additionally,the method of the invention is effective against a wider spectrum ofsuch fungi that can be combated with the active ingredients of thismethod, when used solely.

In general, the weight ratio of component (A) to the mixture ofcomponents (B) and (C) is from 1000:1 to 1:1000, especially from 50:1 to1:50, more especially in a ratio of from 20:1 to 1:20, even moreespecially from 10:1 to 1:10, very especially from 5:1 and 1:5, specialpreference being given to a ratio of from 2:1 to 1:2, and a ratio offrom 4:1 to 2:1 being likewise preferred, above all in a ratio of 1:1,or 5:1, or 5:2, or 5:3, or 5:4, or 4:1, or 4:2, or 4:3, or 3:1, or 3:2,or 2:1, or 1:5, or 2:5, or 3:5, or 4:5, or 1:4, or 2:4, or 3:4, or 1:3,or 2:3, or 1:2, or 1:600, or 1:300, or 1:150, or 1:35, or 2:35, or 4:35,or 1:75, or 2:75, or 4:75, or 1:6000, or 1:3000, or 1:1500, or 1:350, or2:350, or 4:350, or 1:750, or 2:750, or 4:750. Those mixing ratios areunderstood to include, on the one hand, ratios by weight and also, onother hand, molar ratios.

In a preferred embodiment of the invention, the ratios by weight ofcomponent (A) to the mixture of components (B) and (C) are 4:1 to 1:4.

In a preferred embodiment of the invention, ratios by weight ofcomponent (B) to component (C) are from 2:1 to 1:6.

It has been found, surprisingly, that certain weight ratios of component(A) to the mixture of component (B) and (C) are able to give rise tosynergistic activity. Therefore, a further aspect of the invention arecompositions, wherein component (A) and the mixture of component (B) and(C) are present in the composition in amounts producing a synergisticeffect. This synergistic activity is apparent from the fact that thefungicidal activity of the composition comprising component (A) themixture of component (B) and (C) is greater than the sum of thefungicidal activities of component (A) and of the mixture of component(B) and (C). This synergistic activity extends the range of action ofcomponent (A) and the mixture of component (B) and (C) in two ways.Firstly, the rates of application of component (A) and the mixture ofcomponent (B) and (C) are lowered whilst the action remains equallygood, meaning that the active ingredient mixture still achieves a highdegree of phytopathogen control even where the two individual componentshave become totally ineffective in such a low application rate range.Secondly, there is a substantial broadening of the spectrum ofphytopathogens that can be controlled.

A synergistic effect exists whenever the action of an active ingredientcombination is greater than the sum of the actions of the individualcomponents. The action to be expected E for a given active ingredientcombination obeys the so-called COLBY formula and can be calculated asfollows (COLBY, S. R. “Calculating synergistic and antagonisticresponses of herbicide combination”. Weeds, Vol. 15, pages 20-22; 1967):

ppm=milligrams of active ingredient (=a.i.) per liter of spray mixture

X=% action by active ingredient (A) using p ppm of active ingredient

Y=% action by active ingredients (B+C) using q ppm of active ingredient.

Or:

X=% action by active ingredient (A+B) using p ppm of active ingredient

Y=% action by active ingredient (C) using q ppm of active ingredient.

Or:

X=% action by active ingredient (A+C) using p ppm of active ingredient

Y=% action by active ingredient (B) using q ppm of active ingredient.

According to COLBY, the expected (additive) action of active ingredients(A)+(B+C) or (A+B)+(C) or (A+C)+(B) using p+q ppm of active ingredientis

$E = {X + Y - \frac{X \cdot Y}{100}}$

If the action actually observed (O) is greater than the expected action(E), then the action of the combination is super-additive, i.e. there isa synergistic effect. In mathematical terms, synergism corresponds to apositive value for the difference of (O-E). In the case of purelycomplementary addition of activities (expected activity), saiddifference (O-E) is zero. A negative value of said difference (O-E)signals a loss of activity compared to the expected activity.

Synergism can also be calculated by using the following formula:

E (expected value)=X+Y+Z−[(X Y)+(X Z)+(Y Z)/100]+[X Y Z/10000]X, Y, Z=%action by active ingredient (A), (B) and (C) alone using p ppm of activeingredient.

However, besides the actual synergistic action with respect tofungicidal activity, the compositions according to the invention canalso have further surprising advantageous properties. Examples of suchadvantageous properties that may be mentioned are: more advantageuosdegradability; improved toxicological and/or ecotoxicological behaviour;or improved characteristics of the useful plants including: emergence,crop yields, more developed root system, tillering increase, increase inplant height, bigger leaf blade, less dead basal leaves, strongertillers, greener leaf colour, less fertilizers needed, less seedsneeded, more productive tillers, earlier flowering, early grainmaturity, less plant verse (lodging), increased shoot growth, improvedplant vigor, and early germination.

Some compositions according to the invention have a systemic action andcan be used as foliar, soil and seed treatment fungicides.

With the compositions according to the invention it is possible toinhibit or destroy the phytopathogenic microorganisms which occur inplants or in parts of plants (fruit, blossoms, leaves, stems, tubers,roots) in different useful plants, while at the same time the parts ofplants which grow later are also protected from attack byphytopathogenic microorganisms.

The compositions according to the invention can be applied to thephytopathogenic microorganisms, the useful plants, the locus thereof,the propagation material thereof, storage goods or technical materialsthreatened by microorganism attack.

The compositions according to the invention may be applied before orafter infection of the useful plants, the propagation material thereof,storage goods or technical materials by the microorganisms.

A further aspect of the present invention is a method of controllingdiseases on useful plants or on propagation material thereof caused byphytopathogens, which comprises applying to the useful plants, the locusthereof or propagation material thereof a composition according to theinvention. Preferred is a method, which comprises applying to the usefulplants or to the locus thereof a composition according to the invention,more preferably to the useful plants. Further preferred is a method,which comprises applying to the propagation material of the usefulplants a composition according to the invention.

The components (B) and (C) are known. Where the components (B) and (C)are included in “The Pesticide Manual” [The Pesticide Manual - A WorldCompendium; Thirteenth Edition; Editor: C. D. S. Tomlin; The BritishCrop Protection Council], they are described therein under the entrynumber given in round brackets hereinabove for the particular component(B) and (C); for example, the compound “abamectin” is described underentry number (1). Most of the components (B) and (C) are referred tohereinabove by a so-called “common name”, the relevant “ISO common name”or another “common name” being used in individual cases. If thedesignation is not a “common name”, the nature of the designation usedinstead is given in round brackets for the particular component (B) and(C) respectively; in that case, the IUPAC name, the IUPAC/ChemicalAbstracts name, a “chemical name”, a “traditional name”, a “compoundname” or a “develoment code” is used or, if neither one of thosedesignations nor a “common name” is used, an “alternative name” isemployed.

The following components (B) and (C) are registered under a CAS-Reg. No.aldimorph (CAS 91315-15-0); arsenates (CAS 1327-53-3); benalaxyl -M (CAS98243-83-5); benthiavalicarb (CAS 413615-35-7); cadmium chloride (CAS10108-64-2); cedar leaf oil (CAS 8007-20-3); cinnamaldehyde (CAS:104-55-2); copper ammoniumcarbonate (CAS 33113-08-5); copper oleate (CAS1120-44-1); iodocarb (3-Iodo-2-propynyl butyl carbamate) (CAS55406-53-6); hymexazole (CAS 10004-44-1); manganousdimethyldithiocarbamate (CAS 15339-36-3); mercury (CAS 7487-94-7;21908-53-2; 7546-30-7); metrafenone (CAS 220899-03-6); neem oil(hydrophobic extract) (CAS 8002-65-1); orysastrobin CAS 248593-16-0);paraformaldehyde (CAS 30525-89-4); penthiopyrad (CAS 183675-82-3);phosphoric acid (CAS 7664-38-2); potassium bicarbonate (CAS 298-14-6);sodium bicarbonate (CAS 144-55-8); sodium diacetate (CAS 127-09-3);sodium propionate (CAS 137-40-6);TCMTB (CAS 21564-17-0); and tolyfluanid(CAS 731-27-1).

Compound B-1.1 (“enestrobin”) is described in EP-0-936-213; compoundB-3.1 (“flumorph”) in U.S. Pat. No. 6,020,332, CN-1-167-568,CN-1-155-977 and in EP-0-860-438; compound B-5.1 (“mandipropamid”) in WO01/87822; compound B-5.2 in WO 98/46607; compound B-5.3 (“fluopicolide”)in WO 99/42447; compound B-5.4 (“cyflufenamid”) in WO 96/19442; compoundB-5.5 in WO 99/14187; compound B-5.6 (“pyribencarb”) is registered underCAS-Reg. No. 325156-49-8; compound B-5.7 (“amisulbrom” or “ambromdole”)is registered under CAS-Reg. No. 348635-87-0; compound B-5.8(3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid(2-bicyclopropyl-2-yl-phenyl)-amide) is described in WO 03/74491;compound B-5.9 (3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid(9-isopropyp-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide) isdescribed in WO 04/35589 and in WO 06/37632; compound B-5.10(1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxylic acid[2-(1,3-dimethylbutyl)phenyl]-amide) is described in WO 03/10149;compound B-5.11 (3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid(3′,4′-dichloro-5-fluoro-1,1′-biphenyl-2-yl)-amide; “bixafen”) isregistered under CAS-Reg. No.: 581809-46-3 and described in WO 03/70705;compound B-5.12(N-{2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamid;“fluopyram”) is registered under CAS-Reg. No: 658066-35-4 and describedin WO 04/16088; compounds B-5.13, B-5.14 and B-5.15 are described in WO2007/17450; compounds B-5.16, B-5.17 and B-5.18 are described in WO2006/120219. The compound of formula B-7.1 is described in WO 03/015519,the compound of formula B-7.2 is described in WO 2004/067528, thecompound of formula B-7.3 is described in WO 2007/115644. The compoundof formula V is described in WO 2001/094339. Isopyrazam(3-(difluoromethyl)-1-methyl-N-[1,2,3,4-tetrahydro-9-(1-methylethyl)-1,4-methanonaphthalen-5-yl]-1H-pyrazole-4-carboxamide)is described in WO 2004/035589, in WO 2006/037632 and in EP 1556385 andis registered under the CAS-Reg. 881685-58-1. Sedaxane(N-[2-[1,1′-bicyclopropyl]-2-ylphenyl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide)is described in WO 2003/074491 and is registered under the CAS-Reg.874967-67-6; The compound of formula (VI) is described in WO2008/014870; and the compounds of formula (VII) (solatenol,3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid(9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide)is described in WO 2007/048556. Fomesafen is registered under theCAS-Reg. No. 72178-02-0.1-[4-[4-[(5S)5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanoneand1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone(CAS-Reg. No.: 1003318-67-9) are both disclosed in WO 2010/123791, WO2008/013925, WO 2008/013622 and WO 2011/051243 page 20),3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid(3′,4′,5′-trifluoro-biphenyl-2-yl)-amide (fluxapyroxad) is disclosed inWO 2006/087343.

Throughout this document the expression “composition” means the variousmixtures or combinations of components (A) and the mixture of (B) and(C), for example in a single “ready-mix” form, in a combined spraymixture composed from separate formulations of the single activeingredient components, such as a “tank-mix”, and in a combined use ofthe single active ingredients when applied in a sequential manner, i.e.one after the other with a reasonably short period, such as a few hoursor days. The order of applying the components (A) and (B) and (C) is notessential for working the present invention.

As components (A) are compounds of formula I preferred, wherein Q is Q₁,wherein R₁. R₂ and R₃ are preferably halogen, in particular chloro; R ismethoxy and R₈ is hydrogen.

Preferred components (A) are listed in the following Table 1:

TABLE 1 Compounds of formula Ic: (Ic)

wherein Q is (Q₁)

(Q₂)

Compound No. R₁ R₂ R₃ Q R₄ R₅ R₆ R₈ 1.001 Cl Cl Cl Q₁ — — — H 1.002 Cl HCl Q₁ — — — H 1.003 Cl Cl H Q₁ — — — H 1.004 Cl Br Cl Q₁ — — — H 1.005Br Br Br Q₁ — — — H 1.006 H Cl H Q₁ — — — H 1.007 H Br H Q₁ — — — H1.008 H CF₃ H Q₁ — — — H 1.009 — — — Q₂ Cl Cl Cl H 1.010 — — — Q₂ Cl HCl H 1.011 — — — Q₂ H Cl Cl H 1.012 — — — Q₂ Cl Cl Br H 1.013 — — — Q₂Cl H Br H 1.014 — — — Q₂ H Cl Br H 1.015 — — — Q₂ H Cl H H 1.016 — — —Q₂ Cl H H H 1.017 Cl Cl Cl Q₁ — — — OCH₃ 1.018 Cl H Cl Q₁ — — — OCH₃1.019 Cl Cl H Q₁ — — — OCH₃ 1.020 Cl Br Cl Q₁ — — — OCH₃ 1.021 Br Br BrQ₁ — — — OCH₃ 1.022 H Cl H Q₁ — — — OCH₃ 1.023 H Br H Q₁ — — — OCH₃1.024 H CF₃ H Q₁ — — — OCH₃ 1.025 — — — Q₂ Cl Cl Cl OCH₃ 1.026 — — — Q₂Cl H Cl OCH₃ 1.027 — — — Q₂ H Cl Cl OCH₃ 1.028 — — — Q₂ Cl Cl Br OCH₃1.029 — — — Q₂ Cl H Br OCH₃ 1.030 — — — Q₂ H Cl Br OCH₃ 1.031 — — — Q₂ HCl H OCH₃ 1.032 — — — Q₂ Cl H H OCH₃

Further preferred components (A) are listed in the following Table 2:

TABLE 2 Compounds of formula Id: (Id)

wherein Q is (Q₁)

(Q₂)

Compound No. R₁ R₂ R₃ Q R₄ R₅ R₆ R₈ 2.001 Cl Cl Cl Q₁ — — — H 2.002 Cl HCl Q₁ — — — H 2.003 Cl Cl H Q₁ — — — H 2.004 Cl Br Cl Q₁ — — — H 2.005Br Br Br Q₁ — — — H 2.006 H Cl H Q₁ — — — H 2.007 H Br H Q₁ — — — H2.008 H CF₃ H Q₁ — — — H 2.009 — — — Q₂ Cl Cl Cl H 2.010 — — — Q₂ Cl HCl H 2.011 — — — Q₂ H Cl Cl H 2.012 — — — Q₂ Cl Cl Br H 2.013 — — — Q₂Cl H Br H 2.014 — — — Q₂ H Cl Br H 2.015 — — — Q₂ H Cl H H 2.016 — — —Q₂ Cl H H H 2.017 Cl Cl Cl Q₁ — — — OCH₃ 2.018 Cl H Cl Q₁ — — — OCH₃2.019 Cl Cl H Q₁ — — — OCH₃ 2.020 Cl Br Cl Q₁ — — — OCH₃ 2.021 Br Br BrQ₁ — — — OCH₃ 2.022 H Cl H Q₁ — — — OCH₃ 2.023 H Br H Q₁ — — — OCH₃2.024 H CF₃ H Q₁ — — — OCH₃ 2.025 — — — Q₂ Cl Cl Cl OCH₃ 2.026 — — — Q₂Cl H Cl OCH₃ 2.027 — — — Q₂ H Cl Cl OCH₃ 2.028 — — — Q₂ Cl Cl Br OCH₃2.029 — — — Q₂ Cl H Br OCH₃ 2.030 — — — Q₂ H Cl Br OCH₃ 2.031 — — — Q₂ HCl H OCH₃ 2.032 — — — Q₂ Cl H H OCH₃

The following binary mixtures of components (A) with components (B) arepreferred and are defined as members of the group P (the abbreviation“TX” means: “one compound selected from the group consisting of thecompounds specifically described in Tables 1 and 2 of the presentinvention”):

Group P:

azoxystrobin (47)+TX, dimoxystrobin (226)+TX, fluoxastrobin (382)+TX,kresoxim-methyl (485)+TX, metominostrobin (551)+TX, orysastrobin+TX,picoxystrobin (647)+TX, pyraclostrobin (690), trifloxystrobin (832)+TX,a compound of formula B-1.1+TX

azaconazole (40)+TX, bromuconazole (96)+TX, cyproconazole (207)+TX,difenoconazole (247)+TX, diniconazole (267)+TX, diniconazole-M (267)+TX,epoxiconazole (298)+TX, fenbuconazole (329)+TX, fluquinconazole(385)+TX, flusilazole (393)+TX, flutriafol (397)+TX, hexaconazole(435)+TX, imazalil (449)+TX, imibenconazole (457)+TX, ipconazole(468)+TX, metconazole (525)+TX, myclobutanil (564)+TX, oxpoconazole(607)+TX, pefurazoate (618)+TX, penconazole (619)+TX, prochloraz(659)+TX, propiconazole (675)+TX, prothioconazole (685)+TX, simeconazole(731)+TX, tebuconazole (761)+TX, tetraconazole (778)+TX, triadimefon(814)+TX, triadimenol (815)+TX, triflumizole (834)+TX, triticonazole(842)+TX, diclobutrazol (1068)+TX, etaconazole (1129)+TX, furconazole(1198)+TX, furconazole-cis (1199)+TX, quinconazole (1378)+TX,aldimorph+TX, dodemorph (288)+TX, fenpropimorph (344)+TX, tridemorph(830)+TX, fenpropidin (343)+TX, spiroxamine (740)+TX, piperalin(648)+TX, a compound of formula B-3.1+

TX, cyprodinil (208)+TX, mepanipyrim (508)+TX, pyrimethanil (705)+TX;anilazine (878)+TX, arsenates+TX, benalaxyl (56)+TX, benalaxyl-M+TX,benodanil (896)+TX, benomyl (62)+TX, benthiavalicarb+TX,benthiavalicarb-isopropyl (68)+TX, biphenyl (81)+TX, bitertanol (84)+TX,blasticidin-S (85)+TX, bordeaux mixture (87)+TX, boscalid (88)+TX,bupirimate (98)+TX, cadmium chloride+TX, captafol (113)+TX, captan(114)+TX, carbendazim (116)+TX, carbon disulfide (945)+TX, carboxin(120)+TX, carpropamid (122)+TX, cedar leaf oil+TX, chinomethionat(126)+TX, chloroneb (139)+TX, chlorothalonil (142)+TX, chlozolinate(149)+TX, cinnamaldehyde+TX, copper+TX, copper ammoniumcarbonate+TX,copper hydroxide (169)+TX, copper octanoate (170)+TX, copper oleate+TX,copper sulphate (87)+TX, cyazofamid (185)+TX, cycloheximide (1022)+TX,cymoxanil (200)+TX, dichlofluanid (230)+TX, dichlone (1052)+TX,dichloropropene (233)+TX, diclocymet (237)+TX, diclomezine (239)+TX,dicloran (240)+TX, diethofencarb (245)+TX, diflumetorim (253)+TX,dimethirimol (1082)+TX, dimethomorph (263)+TX, dinocap (270)+TX,dithianon (279)+TX, dodine (289)+TX, edifenphos (290)+TX, ethaboxam(304)+TX, ethirimol (1133)+TX, etridiazole (321)+TX, famoxadone(322)+TX, fenamidone (325)+TX, fenaminosulf (1144)+TX, fenamiphos(326)+TX, fenarimol (327)+TX, fenfuram (333)+TX, fenhexamid (334)+TX,fenoxanil (338)+TX, fenpiclonil (341)+TX, fentin acetate (347)+TX,fentin chloride+TX, fentin hydroxide (347)+TX, ferbam (350)+TX,ferimzone (351)+TX, fluazinam (363)+TX, fludioxonil (368)+TX,flusulfamide (394)+TX, flutolanil (396)+TX, folpet (400)+TX,formaldehyde (404)+TX, fosetyl-aluminium (407)+TX, fthalide (643)+TX,fuberidazole (419)+TX, furalaxyl (410)+TX, furametpyr (411)+TX, flyodin(1205)+TX, fuazatine (422)+TX, hexachlorobenzene (434)+TX,hymexazole+TX, iminoctadine tris(albesliate) [99257-43-9]+TX, iodocarb(3-Iodo-2-propynyl butyl carbamate)+TX, iprobenfos (IBP) (469)+TX,iprodione (470)+TX, iprovalicarb (471)+TX, isoprothiolane (474)+TX,kasugamycin (483)+TX, mancozeb (496)+TX, maneb (497)+TX, manganousdimethyldithiocarbamate+TX, mefenoxam (Metalaxyl-M) (517)+TX, mepronil(510)+TX, mercuric chloride (511)+TX, mercury+TX, metalaxyl (516)+TX,methasulfocarb (528)+TX, metiram (546)+TX, metrafenone+TX, nabam(566)+TX, neem oil (hydrophobic extract)+TX, nuarimol (587)+TX,octhilinone (590)+TX, ofurace (592)+TX, oxadixyl (601)+TX, oxine copper(605)+TX, oxolinic acid (606)+TX, oxycarboxin (608)+TX, oxytetracycline(611)+TX, paclobutrazole (612)+TX, paraffin oil (628)+TX,paraformaldehyde+TX, pencycuron (620)+TX, pentachloronitrobenzene(716)+TX, pentachlorophenol (623)+TX, penthiopyrad+TX, perfurazoate+TX,phosphoric acid+TX, polyoxin (654)+TX, polyoxin D zinc salt (654)+TX,potassium bicarbonate+TX, probenazole (658)+TX, procymidone (660)+TX,propamocarb (668)+TX, propineb (676)+TX, proquinazid (682)+TX,prothiocarb (1361)+TX, pyrazophos (693)+TX, pyrifenox (703)+TX,pyroquilon (710)+TX, quinoxyfen (715)+TX, quintozene (PCN(B) (716)+TX,silthiofam (729)+TX, sodium bicarbonate+TX, sodium diacetate+TX, sodiumpropionate+TX, streptomycin (744)+TX, sulphur (754)+TX, TCMTB+TX,tecloftalam+TX, tecnazene (TCN(B) (767)+TX, thiabendazole (790)+TX,thifluzamide (796)+TX, thiophanate (1435)+TX, thiophanate-methyl(802)+TX, thiram (804)+TX, tolclofos-methyl (808)+TX, tolylfluanid(810)+TX, triazoxide (821)+TX, trichoderma harzianum (825)+TX,tricyclazole (828)+TX, triforine (838)+TX, triphenyltin hydroxide(347)+TX, validamycin (846)+TX, vinclozolin (849)+TX, zineb (855)+TX,ziram (856)+TX, zoxamide (857)+TX,1+TX,1-bis(4-chlorophenyl)-2-ethoxyethanol (IUPAC-Name) (910)+TX,2,4-dichlorophenyl benzenesulfonate (IUPAC-/Chemical Abstracts-Name)(1059)+TX, 2-fluoro-N-methyl-N-1-naphthylacetamide (IUPAC-Name)(1295)+TX, 4-chlorophenyl phenyl sulfone (IUPAC-Name) (981)+TX, acompound of formula B-5.1+TX, a compound of formula B-5.2+TX, a compoundof formula B-5.3+TX, a compound of formula B-5.4+TX, a compound offormula B-5.5+TX, a compound of formula B-5.6+TX, a compound of formulaB-5.7+TX, compound B-5 5.8+TX, compound B-5.9+TX, compound B-5.10+TX,bixafen+TX, fluopyram+TX, compound B-5.13+TX, compound B-5.14+TX,compound B-5.15+TX, compound B-5.16+TX, compound B-5.17+TX and compoundB-5.18+TX, acibenzolar-S-methyl (6)+TX, chlormequat chloride (137)+TX,ethephon (307)+TX, mepiquat chloride (509)+TX, trinexapac-ethyl(841)+TX, abamectin (1)+TX, clothianidin (165)+TX, emamectin benzoate(291)+TX, imidacloprid (458)+TX, tefluthrin (769)+TX, thiamethoxam(792)+TX, and glyphosate (419)+TX, a compound of formula V

fomesafen+TX, isopyrazam+TX, sedaxane+TX,

the compound of formula (VI)+TX

the compound of formula (VII)+TX

1-[4-[4-[(5S)5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone+TX,1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-l-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone+TX,fluxapyroxad+TX, phosphorous acid+TX, phosphorous acid sodium salt+TXand phosphorous acid ammonium salt+TX.

Especially preferred compositions according to the present invention aredefined in the following Table 3 as embodiments E1 to E21. The term TX1means “one mixture selected from the group P”. The compositions whereincomponent (B) from the group P is identical to component (C) areexcluded. The compositions comprising a compound of formula I accordingto tables 1 and 2+azoxystrobin+cyproconazole are excluded.

TABLE 3 preferred mixtures according to this invention: EmbodimentComponent C E1 compound of formula VII + TX1 E2 fluxapyroxad + TX1 E3bixafen + TX1 E4 penthiopyrad + TX1 E5 fluopyram + TX1 E6 boscalid + TX1E7 isopyrazam + TX1 E8 propiconazole + TX1 E9 cyproconazole + TX1 E10difenoconazole + TX1 E11 prothioconazole + TX1 E12 iminoctadinetris(albesilate) + TX1 E13 thiabendazole + TX1 E14 azoxystrobin + TX1E15 thiophanate methyl + TX1 E16 tebuconazole + TX1 E17trifloxystrobin + TX1 E18 pyraclostrobin + TX1 E19 fludioxonil + TX1 E20cyprodinil + TX1 E21 fluazinam + TX1

For example, embodiment E1 consists of the following ternary mixtures:azoxystrobin (47)+TX+the compound of formula VII, dimoxystrobin(226)+TX+the compound of formula VII, fluoxastrobin (382)+TX+thecompound of formula VII, kresoxim-methyl (485)+TX+the compound offormula VII, metominostrobin (551)+TX+the compound of formula VII,orysastrobin+TX+the compound of formula VII, picoxystrobin (647)+TX+thecompound of formula VII, pyraclostrobin (690)+TX+the compound of formulaVII, trifloxystrobin (832)+TX+the compound of formula VII, a compound offormula B-1.1

+TX+the compound of formula VII, azaconazole (40)+TX+the compound offormula VII, bromuconazole (96)+TX+the compound of formula VII,cyproconazole (207)+TX+the compound of formula VII, difenoconazole(247)+TX+the compound of formula VII, diniconazole (267)+TX+the compoundof formula VII, diniconazole-M (267)+TX+the compound of formula VII,epoxiconazole (298)+TX+the compound of formula VII, fenbuconazole(329)+TX+the compound of formula VII, fluquinconazole (385)+TX+thecompound of formula VII, flusilazole (393)+TX+the compound of formulaVII, flutriafol (397)+TX+the compound of formula VII, hexaconazole(435)+TX+the compound of formula VII, imazalil (449)+TX+the compound offormula VII, imibenconazole (457)+TX+the compound of formula VII,ipconazole (468)+TX+the compound of formula VII, metconazole(525)+TX+the compound of formula VII, myclobutanil (564)+TX+the compoundof formula VII, oxpoconazole (607)+TX+the compound of formula VII,pefurazoate (618)+TX+the compound of formula VII, penconazole(619)+TX+the compound of formula VII, prochloraz (659)+TX+the compoundof formula VII, propiconazole (675)+TX+the compound of formula VII,prothioconazole (685)+TX+the compound of formula VII, simeconazole(731)+TX+the compound of formula VII, tebuconazole (761)+TX+the compoundof formula VII, tetraconazole (778)+TX+the compound of formula VII,triadimefon (814)+TX+the compound of formula VII, triadimenol(815)+TX+the compound of formula VII, triflumizole (834)+TX+the compoundof formula VII, triticonazole (842)+TX+the compound of formula VII,diclobutrazol (1068)+TX+the compound of formula VII, etaconazole(1129)+TX+the compound of formula VII, furconazole (1198)+TX+thecompound of formula VII, furconazole-cis (1199)+TX+the compound offormula VII, quinconazole (1378)+TX+the compound of formula VII,aldimorph+TX+the compound of formula VII, dodemorph (288)+TX+thecompound of formula VII, fenpropimorph (344)+TX+the compound of formulaVII, tridemorph (830)+TX+the compound of formula VII, fenpropidin(343)+TX+the compound of formula VII, spiroxamine (740)+TX+the compoundof formula VII, piperalin (648)+TX+the compound of formula VII, acompound of formula B-3.1

+TX+the compound of formula VII, cyprodinil (208)+TX+the compound offormula VII, mepanipyrim (508)+TX+the compound of formula VII,pyrimethanil (705)+TX+the compound of formula VII, anilazine(878)+TX+the compound of formula VII, arsenates+TX+the compound offormula VII, benalaxyl (56)+TX+the compound of formula VII,benalaxyl-M+TX+the compound of formula VII, benodanil (896)+TX+thecompound of formula VII, benomyl (62)+TX+the compound of formula VII,benthiavalicarb+TX+the compound of formula VII,benthiavalicarb-isopropyl (68)+TX+the compound of formula VII, biphenyl(81)+TX+the compound of formula VII, bitertanol (84)+TX+the compound offormula VII, blasticidin-S (85)+TX+the compound of formula VII, bordeauxmixture (87)+TX+the compound of formula VII, boscalid (88)+TX+thecompound of formula VII, bupirimate (98)+TX+the compound of formula VII,cadmium chloride+TX+the compound of formula VII, captafol (113)+TX+thecompound of formula VII, captan (114)+TX+the compound of formula VII,carbendazim (116)+TX+the compound of formula VII, carbon disulfide(945)+TX+the compound of formula VII, carboxin (120)+TX+the compound offormula VII, carpropamid (122)+TX+the compound of formula VII, cedarleaf oil+TX+the compound of formula VII, chinomethionat (126)+TX+thecompound of formula VII, chloroneb (139)+TX+the compound of formula VII,chlorothalonil (142)+TX+the compound of formula VII, chlozolinate(149)+TX+the compound of formula VII, cinnamaldehyde+TX+the compound offormula VII, copper+TX+the compound of formula VII, copperammoniumcarbonate+TX+the compound of formula VII, copper hydroxide(169)+TX+the compound of formula VII, copper octanoate (170)+TX+thecompound of formula VII, copper oleate+TX+the compound of formula VII,copper sulphate (87)+TX+the compound of formula VII, cyazofamid(185)+TX+the compound of formula VII, cycloheximide (1022)+TX+thecompound of formula VII, cymoxanil (200)+TX+the compound of formula VII,dichlofluanid (230)+TX+the compound of formula VII, dichlone(1052)+TX+the compound of formula VII, dichloropropene (233)+TX+thecompound of formula VII, diclocymet (237)+TX+the compound of formulaVII, diclomezine (239)+TX+the compound of formula VII, dicloran(240)+TX+the compound of formula VII, diethofencarb (245)+TX+thecompound of formula VII, diflumetorim (253)+TX+the compound of formulaVII, dimethirimol (1082)+TX+the compound of formula VII, dimethomorph(263)+TX+the compound of formula VII, dinocap (270)+TX+the compound offormula VII, dithianon (279)+TX+the compound of formula VII, dodine(289)+TX+the compound of formula VII, edifenphos (290)+TX+the compoundof formula VII, ethaboxam (304)+TX+the compound of formula VII,ethirimol (1133)+TX+the compound of formula VII, etridiazole(321)+TX+the compound of formula VII, famoxadone (322)+TX+the compoundof formula VII, fenamidone (325)+TX+the compound of formula VII,fenaminosulf (1144)+TX+the compound of formula VII, fenamiphos(326)+TX+the compound of formula VII, fenarimol (327)+TX+the compound offormula VII, fenfuram (333)+TX+the compound of formula VII, fenhexamid(334)+TX+the compound of formula VII, fenoxanil (338)+TX+the compound offormula VII, fenpiclonil (341)+TX+the compound of formula VII, fentinacetate (347)+TX+the compound of formula VII, fentin chloride+TX+thecompound of formula VII, fentin hydroxide (347)+TX+the compound offormula VII, ferbam (350)+TX+the compound of formula VII, ferimzone(351)+TX+the compound of formula VII, fluazinam (363)+TX+the compound offormula VII, fludioxonil (368)+TX+the compound of formula VII,flusulfamide (394)+TX+the compound of formula VII, flutolanil(396)+TX+the compound of formula VII, folpet (400)+TX+the compound offormula VII, formaldehyde (404)+TX+the compound of formula VII,fosetyl-aluminium (407)+TX+the compound of formula VII, fthalide(643)+TX+the compound of formula VII, fuberidazole (419)+TX+the compoundof formula VII, furalaxyl (410)+TX+the compound of formula VII,furametpyr (411)+TX+the compound of formula VII, flyodin (1205)+TX+thecompound of formula VII, fuazatine (422)+TX+the compound of formula VII,hexachlorobenzene (434)+TX+the compound of formula VII,hymexazole+TX+the compound of formula VII, iminoctadine tris(albesliate)(CAS Reg. No. 99257-43-9)+TX+the compound of formula VII, iodocarb(3-Iodo-2-propynyl butyl carbamate)+TX+the compound of formula VII,iprobenfos (IBP) (469)+TX+the compound of formula VII, iprodione(470)+TX+the compound of formula VII, iprovalicarb (471)+TX+the compoundof formula VII, isoprothiolane (474)+TX+the compound of formula VII,kasugamycin (483)+TX+the compound of formula VII, mancozeb (496)+TX+thecompound of formula VII, maneb (497)+TX+the compound of formula VII,manganous dimethyldithiocarbamate+TX+the compound of formula VII,mefenoxam (Metalaxyl-M) (517)+TX+the compound of formula VII, mepronil(510)+TX+the compound of formula VII, mercuric chloride (511)+TX+thecompound of formula VII, mercury+TX+the compound of formula VII,metalaxyl (516)+TX+the compound of formula VII, methasulfocarb(528)+TX+the compound of formula VII, metiram (546)+TX+the compound offormula VII, metrafenone+TX+the compound of formula VII, nabam(566)+TX+the compound of formula VII, neem oil (hydrophobicextract)+TX+the compound of formula VII, nuarimol (587)+TX+the compoundof formula VII, octhilinone (590)+TX+the compound of formula VII,ofurace (592)+TX+the compound of formula VII, oxadixyl (601)+TX+thecompound of formula VII, oxine copper (605)+TX+the compound of formulaVII, oxolinic acid (606)+TX+the compound of formula VII, oxycarboxin(608)+TX+the compound of formula VII, oxytetracycline (611)+TX+thecompound of formula VII, paclobutrazole (612)+TX+the compound of formulaVII, paraffin oil (628)+TX+the compound of formula VII,paraformaldehyde+TX+the compound of formula VII, pencycuron (620)+TX+thecompound of formula VII, pentachloronitrobenzene (716)+TX+the compoundof formula VII, pentachlorophenol (623)+TX+the compound of formula VII,penthiopyrad+TX+the compound of formula VII, perfurazoate+TX+thecompound of formula VII, phosphoric acid+TX+the compound of formula VII,polyoxin (654)+TX+the compound of formula VII, polyoxin D zinc salt(654)+TX+the compound of formula VII, potassium bicarbonate+TX+thecompound of formula VII, probenazole (658)+TX+the compound of formulaVII, procymidone (660)+TX+the compound of formula VII, propamocarb(668)+TX+the compound of formula VII, propineb (676)+TX+the compound offormula VII, proquinazid (682)+TX+the compound of formula VII,prothiocarb (1361)+TX+the compound of formula VII, pyrazophos(693)+TX+the compound of formula VII, pyrifenox (703)+TX+the compound offormula VII, pyroquilon (710)+TX+the compound of formula VII, quinoxyfen(715)+TX+the compound of formula VII, quintozene (PCN(B) (716)+TX+thecompound of formula VII, silthiofam (729)+TX+the compound of formulaVII, sodium bicarbonate+TX+the compound of formula VII, sodiumdiacetate+TX+the compound of formula VII, sodium propionate+TX+thecompound of formula VII, streptomycin (744)+TX+the compound of formulaVII, sulphur (754)+TX+the compound of formula VII, TCMTB+TX+the compoundof formula VII, tecloftalam+TX+the compound of formula VII, tecnazene(TCN(B) (767)+TX+the compound of formula VII, thiabendazole (790)+TX+thecompound of formula VII, thifluzamide (796)+TX+the compound of formulaVII, thiophanate (1435)+TX+the compound of formula VII,thiophanate-methyl (802)+TX+the compound of formula VII, thiram(804)+TX+the compound of formula VII, tolclofos-methyl (808)+TX+thecompound of formula VII, tolylfluanid (810)+TX+the compound of formulaVII, triazoxide (821)+TX+the compound of formula VII, trichodermaharzianum (825)+TX+the compound of formula VII, tricyclazole(828)+TX+the compound of formula VII, triforine (838)+TX+the compound offormula VII, triphenyltin hydroxide (347)+TX+the compound of formulaVII, validamycin (846)+TX+the compound of formula VII, vinclozolin(849)+TX+the compound of formula VII, zineb (855)+TX+the compound offormula VII, ziram (856)+TX+the compound of formula VII, zoxamide(857)+TX+the compound of formula VII, 1+TX+the compound of formula VII,1-bis(4-chlorophenyl)-2-ethoxyethanol (IUPAC-Name) (910)+TX+the compoundof formula VII, 2+TX+the compound of formula VII, 2,4-dichlorophenylbenzenesulfonate (IUPAC-/Chemical Abstracts-Name) (1059)+TX+the compoundof formula VII, 2-fluoro-N-methyl-N-1-naphthylacetamide (IUPAC-Name)(1295)+TX+the compound of formula VII, 4-chlorophenyl phenyl sulfone(IUPAC-Name) (981)+TX+the compound of formula VII, a compound of formulaB-5.1+TX+the compound of formula VII, a compound of formula B-5.2+TX+thecompound of formula VII, a compound of formula B-5.3+TX+the compound offormula VII, a compound of formula B-5.4+TX+the compound of formula VII,a compound of formula B-5.5+TX+the compound of formula VII, a compoundof formula B-5.6+TX+the compound of formula VII, a compound of formulaB-5.7+TX+the compound of formula VII, the compound B-5.8+TX+the compoundof formula VII, the compound B-5.9+TX+the compound of formula VII,compound B-5.10+TX+the compound of formula VII, bixafen+TX+the compoundof formula VII, fluopyram+TX+the compound of formula VII, the compoundB-5.13+TX+the compound of formula VII, the compound B-5.14+TX+thecompound of formula VII, the compound B-5.15+TX+the compound of formulaVII, the compound B-5.16+TX+the compound of formula VII, the compoundB-5.17+TX+the compound of formula VII, the compound B-5.18+TX+thecompound of formula VII, acibenzolar-S-methyl (6)+TX+the compound offormula VII, chlormequat chloride (137)+TX+the compound of formula VII,ethephon (307)+TX+the compound of formula VII, mepiquat chloride(509)+TX+the compound of formula VII, trinexapac-ethyl (841)+TX+thecompound of formula VII, abamectin (1)+TX+the compound of formula VII,clothianidin (165)+TX+the compound of formula VII, emamectin benzoate(291)+TX+the compound of formula VII, imidacloprid (458)+TX+the compoundof formula VII, tefluthrin (769)+TX+the compound of formula VII,thiamethoxam (792)+TX+the compound of formula VII, glyphosate(419)+TX+the compound of formula VII, a compound of formula V

(V)+TX+the compound of formula VII, fomesafen+TX+the compound of formulaVII, isopyrazam+TX+the compound of formula VII, sedaxane+TX+the compoundof formula VII, the compound of formula (VI)

+TX+the compound of formula VII,1-[4-[4-[(5S)5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone+TX+thecompound of formula VII,1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone+TX+thecompound of formula VII, fluxapyroxad+TX+the compound of formula VII,phosphorous acid +TX+the compound of formula VII, phosphorous acidsodium salt+TX+the compound of formula VII and phosphorous acid ammoniumsalt+TX+the compound of formula VII.

The active ingredient combinations (A)+(B)+(C) can additionally containphosphorous acid (IUPAC name phosphonic acid) and salts of phosphorousacid, particularly the sodium, potassium and ammonium salt. Phosphorousacid and salts of phosphorous acid, particularly the sodium, potassiumand ammonium salt can also be mixed with components (A)+(B) and (A)+(C).The mixture of components (A)+(B)+(C) with phosphorous acid and salts ofphosphorous acid, particularly the sodium, potassium and ammonium saltrepresents a further embodiment of the invention.

A preferred component (A) is the compound No. 1.001(3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide).Preferred pre-mixtures which comprise component (A) and component (B)ready to mix with component (C) are selected from the group consistingof

the compound No. 1.001+the compound of formula VII

the compound No. 1.001+isopyrazam

the compound No. 1.001+difenoconazole

the compound No. 1.001+azoxystrobin

the compound No. 1.001+prothioconazole

the compound No. 1.001+tebuconazole

the compound No. 1.001+pyraclostrobin

the compound No. 1.001+trifloxystrobin

the compound No. 1.001+fludioxonil and

the compound No. 1.001+cyprodinil.

Preferred components (C) for the mixture with pre-mixtures of components(A) and (B) mentioned above are selected from the group consisting ofthe compound of formula VII, fluxapyroxad, bixafen, penthiopyrad,fluopyram, boscalid, isopyrazam, propiconazole, cyproconazole,difenoconazole, prothioconazole, thiabendazole azoxystrobin, thiophanatemethyl and iminoctadine tris(albesilate), with the proviso that in eachcomposition component (B) is different from component (C).

Especially preferred components (C) for the mixture with pre-mixtures ofcomponents (A) and (B) mentioned above are selected from the groupconsisting of isopyrazam, difenoconazole, azoxystrobin, prothioconazole,tebuconazole, pyraclostrobin, trifloxystrobin, fludioxonil, cyprodiniland fluazinam, with the proviso that in each composition component (B)is different from component (C).

Especially preferred embodiments of the present invention are areselected from the following mixtures of active ingredients:

the compound No. 1.001+the compound of formula VII+isopyrazam;

the compound No. 1.001+the compound of formula VII+difenoconazole;

the compound No. 1.001+the compound of formula VII+azoxystrobin;

the compound No. 1.001+the compound of formula VII+prothioconazole;

the compound No. 1.001+the compound of formula VII+tebuconazole;

the compound No. 1.001+the compound of formula VII+pyraclostrobin;

the compound No. 1.001+the compound of formula VII+trifloxystrobin;

the compound No. 1.001+the compound of formula VII+fludioxonil;

the compound No. 1.001+the compound of formula VII+cyprodinil;

the compound No. 1.001+the compound of formula VII+fluazinam;

the compound No. 1.001+isopyrazam+difenoconazole;

the compound No. 1.001+isopyrazam+azoxystrobin;

the compound No. 1.001+isopyrazam+prothioconazole;

the compound No. 1.001+isopyrazam+tebuconazole;

the compound No. 1.001+isopyrazam+pyraclostrobin;

the compound No. 1.001+isopyrazam+trifloxystrobin;

the compound No. 1.001+isopyrazam+fludioxonil;

the compound No. 1.001+isopyrazam+cyprodinil;

the compound No. 1.001+isopyrazam+fluazinam;

the compound No. 1.001+difenoconazole+azoxystrobin;

the compound No. 1.001+difenoconazole+prothioconazole;

the compound No. 1.001+difenoconazole+tebuconazole;

the compound No. 1.001+difenoconazole+pyraclostrobin;

the compound No. 1.001+difenoconazole+trifloxystrobin;

the compound No. 1.001+difenoconazole+fludioxonil;

the compound No. 1.001+difenoconazole+cyprodinil;

the compound No. 1.001+difenoconazole+fluazinam;

the compound No. 1.001+azoxystrobin+prothioconazole;

the compound No. 1.001+azoxystrobin+tebuconazole;

the compound No. 1.001+azoxystrobin+pyraclostrobin;

the compound No. 1.001+azoxystrobin+trifloxystrobin;

the compound No. 1.001+azoxystrobin+fludioxonil;

the compound No. 1.001+azoxystrobin+cyprodinil;

the compound No. 1.001+azoxystrobin+fluazinam;

the compound No. 1.001+prothioconazole+tebuconazole;

the compound No. 1.001+prothioconazole+pyraclostrobin;

the compound No. 1.001+prothioconazole+trifloxystrobin;

the compound No. 1.001+prothioconazole+fludioxonil;

the compound No. 1.001+prothioconazole+cyprodinil;

the compound No. 1.001+prothioconazole+fluazinam;

the compound No. 1.001+tebuconazole+pyraclostrobin;

the compound No. 1.001+tebuconazole+trifloxystrobin;

the compound No. 1.001+tebuconazole+fludioxonil;

the compound No. 1.001+tebuconazole+cyprodinil;

the compound No. 1.001+tebuconazole+fluazinam;

the compound No. 1.001+pyraclostrobin+trifloxystrobin;

the compound No. 1.001+pyraclostrobin+fludioxonil;

the compound No. 1.001+pyraclostrobin+cyprodinil;

the compound No. 1.001+pyraclostrobin+fluazinam;

the compound No. 1.001+trifloxystrobin+fludioxonil;

the compound No. 1.001+trifloxystrobin+cyprodinil;

the compound No. 1.001+trifloxystrobin+fluazinam;

the compound No. 1.001+fludioxonil+cyprodinil;

the compound No. 1.001+fludioxonil+fluazinam; and

the compound No. 1.001+cyprodinil+fluazinam.

The active ingredient combinations are effective against harmfulmicroorganisms, such as microorganisms, that cause phytopathogenicdiseases, in particular against phytopathogenic fungi and bacteria.

The active ingredient combinations are effective especially againstphytopathogenic fungi belonging to the following classes: Ascomycetes(e.g. Venturia, Podosphaera, Erysiphe, Monilinia, Mycosphaerella,Uncinula); Basidiomycetes (e.g. the genus Hemileia, Rhizoctonia,Phakopsora, Puccinia, Ustilago, Tilletia); Fungi imperfecti (also knownas Deuteromycetes; e.g. Botrytis, Helminthosporium, Rhynchosporium,Fusarium, Septoria, Cercospora, Alternaria, Pyricularia andPseudocercosporella); Oomycetes (e.g. Phytophthora, Peronospora,Pseudoperonospora, Albugo, Bremia, Pythium, Pseudosclerospora,Plasmopara).

According to the invention “useful plants” typically comprise thefollowing species of plants: grape vines; cereals, such as wheat,barley, rye or oats; beet, such as sugar beet or fodder beet; fruits,such as pomes, stone fruits or soft fruits, for example apples, pears,plums, peaches, almonds, cherries, strawberries, raspberries orblackberries; leguminous plants, such as beans, lentils, peas orsoybeans; oil plants, such as rape, mustard, poppy, olives, sunflowers,coconut, castor oil plants, cocoa beans or groundnuts; cucumber plants,such as marrows, cucumbers or melons; fibre plants, such as cotton,flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruit ormandarins; vegetables, such as spinach, lettuce, asparagus, cabbages,carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceae,such as avocados, cinnamon or camphor; maize; tobacco; nuts; coffee;sugar cane; tea; vines; hops; durian; bananas; natural rubber plants;turf or ornamentals, such as flowers, shrubs, broad-leaved trees orevergreens, for example conifers. This list does not represent anylimitation.

The term “useful plants” is to be understood as including also usefulplants that have been rendered tolerant to herbicides like bromoxynil orclasses of herbicides (such as, for example, HPPD inhibitors, ALSinhibitors, for example primisulfuron, prosulfuron and trifloxysulfuron,EPSPS (5-enol-pyrovyl-shikimate-3-phosphate-synthase) inhibitors, GS(glutamine synthetase) inhibitors) as a result of conventional methodsof breeding or genetic engineering. An example of a crop that has beenrendered tolerant to imidazolinones, e.g. imazamox, by conventionalmethods of breeding (mutagenesis) is Clearfield® summer rape (Canola).Examples of crops that have been rendered tolerant to herbicides orclasses of herbicides by genetic engineering methods include glyphosate-and glufosinate-resistant maize varieties commercially available underthe trade names RoundupReady®, Herculex I® and LibertyLink®.

The term “useful plants” is to be understood as including also usefulplants which have been so transformed by the use of recombinant DNAtechniques that they are capable of synthesising one or more selectivelyacting toxins, such as are known, for example, from toxin-producingbacteria, especially those of the genus Bacillus.

Toxins that can be expressed by such transgenic plants include, forexample, insecticidal proteins, for example insecticidal proteins fromBacillus cereus or Bacillus popliae; or insecticidal proteins fromBacillus thuringiensis, such as δ-endotoxins, e.g. CryIA(b), CryIA(c),CryIF, CryIF(a2), CryIIA(b), CryIIIA, CryIIIB(b1) or Cry9c, orvegetative insecticidal proteins (VIP), e.g. VIP1, VIP2, VIP3 or VIP3A;or insecticidal proteins of bacteria colonising nematodes, for examplePhotorhabdus spp. or Xenorhabdus spp., such as Photorhabdus luminescens,Xenorhabdus nematophilus; toxins produced by animals, such as scorpiontoxins, arachnid toxins, wasp toxins and other insect-specificneurotoxins; toxins produced by fungi, such as Streptomycetes toxins,plant lectins, such as pea lectins, barley lectins or snowdrop lectins;agglutinins; proteinase inhibitors, such as trypsine inhibitors, serineprotease inhibitors, patatin, cystatin, papain inhibitors;ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin,luffin, saporin or bryodin; steroid metabolism enzymes, such as3-hydroxysteroidoxidase, ecdysteroid-UDP-glycosyl-transferase,cholesterol oxidases, ecdysone inhibitors, HMG-COA-reductase, ionchannel blockers, such as blockers of sodium or calcium channels,juvenile hormone esterase, diuretic hormone receptors, stilbenesynthase, bibenzyl synthase, chitinases and glucanases.

In the context of the present invention there are to be understood byδ-endotoxins, for example CryIA(b), CryIA(c), CryIF, CryIF(a2),CryIIA(b), CryIIIA, CryIIIB(b1) or Cry9c, or vegetative insecticidalproteins (VIP), for example VIP1, VIP2, VIP3 or VIP3A, expressly alsohybrid toxins, truncated toxins and modified toxins. Hybrid toxins areproduced recombinantly by a new combination of different domains ofthose proteins (see, for example, WO 02/15701). An example for atruncated toxin is a truncated CryIA(b), which is expressed in the Bt11maize from Syngenta Seed SAS, as described below. In the case ofmodified toxins, one or more amino acids of the naturally occurringtoxin are replaced. In such amino acid replacements, preferablynon-naturally present protease recognition sequences are inserted intothe toxin, such as, for example, in the case of CryIIIA055, acathepsin-D-recognition sequence is inserted into a CryIIIA toxin (seeWO 03/018810)

Examples of such toxins or transgenic plants capable of synthesisingsuch toxins are disclosed, for example, in EP-A-0 374 753, WO 93/07278,WO 95/34656, EP-A-0 427 529, EP-A-451 878 and WO 03/052073.

The processes for the preparation of such transgenic plants aregenerally known to the person skilled in the art and are described, forexample, in the publications mentioned above. CryI-type deoxyribonucleicacids and their preparation are known, for example, from WO 95/34656,EP-A-0 367 474, EP-A-0 401 979 and WO 90/13651.

The toxin contained in the transgenic plants imparts to the plantstolerance to harmful insects. Such insects can occur in any taxonomicgroup of insects, but are especially commonly found in the beetles(Coleoptera), two-winged insects (Diptera) and butterflies(Lepidoptera).

Transgenic plants containing one or more genes that code for aninsecticidal resistance and express one or more toxins are known andsome of them are commercially available. Examples of such plants are:YieldGard® (maize variety that expresses a CryIA(b) toxin); YieldGardRootworm® (maize variety that expresses a CryIIIB(b1) toxin); YieldGardPlus® (maize variety that expresses a CryIA(b) and a CryIIIB(b1) toxin);Starlink® (maize variety that expresses a Cry9(c) toxin); Herculex I®(maize variety that expresses a CryIF(a2) toxin and the enzymephosphinothricine N-acetyltransferase (PAT) to achieve tolerance to theherbicide glufosinate ammonium); NuCOTN 33B® (cotton variety thatexpresses a CryIA(c) toxin); Bollgard I® (cotton variety that expressesa CryIA(c) toxin); Bollgard II® (cotton variety that expresses aCryIA(c) and a CryIIA(b) toxin); VIPCOT® (cotton variety that expressesa VIP toxin); NewLeaf® (potato variety that expresses a CryIIIA toxin);NatureGard® and Protecta®.

Further examples of such transgenic crops are:

1. Bt11 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790St. Sauveur, France, registration number C/FR/96/05/10. Geneticallymodified Zea mays which has been rendered resistant to attack by theEuropean corn borer (Ostrinia nubilalis and Sesamia nonagrioides) bytransgenic expression of a truncated CryIA(b) toxin. Bt11 maize alsotransgenically expresses the enzyme PAT to achieve tolerance to theherbicide glufosinate ammonium.

2. Bt176 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790St. Sauveur, France, registration number C/FR/96/05/10. Geneticallymodified Zea mays which has been rendered resistant to attack by theEuropean corn borer (Ostrinia nubilalis and Sesamia nonagrioides) bytransgenic expression of a CryIA(b) toxin. Bt176 maize alsotransgenically expresses the enzyme PAT to achieve tolerance to theherbicide glufosinate ammonium.

3. MIR604 Maize from Syngenta Seeds SAS, Chemin de I'Hobit 27, F-31 790St. Sauveur, France, registration number C/FR/96/05/10. Maize which hasbeen rendered insect-resistant by transgenic expression of a modifiedCryIIIA toxin. This toxin is Cry3A055 modified by insertion of acathepsin-D-protease recognition sequence. The preparation of suchtransgenic maize plants is described in WO 03/018810.

4. MON 863 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren,B-1150 Brussels, Belgium, registration number C/DE/02/9. MON 863expresses a CryIIIB(b1) toxin and has resistance to certain Coleopterainsects.

5. IPC 531 Cotton from Monsanto Europe S.A. 270-272 Avenue de Tervuren,B-1150 Brussels, Belgium, registration number C/ES/96/02.

6. 1507 Maize from Pioneer Overseas Corporation, Avenue Tedesco, 7B-1160 Brussels, Belgium, registration number C/NL/00/10. Geneticallymodified maize for the expression of the protein CryI F for achievingresistance to certain Lepidoptera insects and of the PAT protein forachieving tolerance to the herbicide glufosinate ammonium.

7. NK603×MON 810 Maize from Monsanto Europe S.A. 270-272 Avenue deTervuren, B-1150 Brussels, Belgium, registration number C/GB/02/M3/03.Consists of conventionally bred hybrid maize varieties by crossing thegenetically modified varieties NK603 and MON 810. NK603×MON 810 Maizetransgenically expresses the protein CP4 EPSPS, obtained fromAgrobacterium sp. strain CP4, which imparts tolerance to the herbicideRoundup® (contains glyphosate), and also a CryIA(b) toxin obtained fromBacillus thuringiensis subsp. kurstaki which brings about tolerance tocertain Lepidoptera, include the European corn borer. Transgenic cropsof insect-resistant plants are also described in BATS (Zentrum fürBiosicherheit and Nachhaltigkeit, Zentrum BATS, Clarastrasse 13, 4058Basel, Switzerland) Report 2003, (http://bats.ch).

The term “useful plants” is to be understood as including also usefulplants which have been so transformed by the use of recombinant DNAtechniques that they are capable of synthesising antipathogenicsubstances having a selective action, such as, for example, theso-called “pathogenesis-related proteins” (PRPs, see e.g. EP-A-0 392225). Examples of such antipathogenic substances and transgenic plantscapable of synthesising such antipathogenic substances are known, forexample, from EP-A-0 392 225, WO 95/33818, and EP-A-0 353 191.

The methods of producing such transgenic plants are generally known tothe person skilled in the art and are described, for example, in thepublications mentioned above.

Antipathogenic substances which can be expressed by such transgenicplants include, for example, ion channel blockers, such as blockers forsodium and calcium channels, for example the viral KP1, KP4 or KP6toxins; stilbene synthases; bibenzyl synthases; chitinases; glucanases;the so-called “pathogenesis-related proteins” (PRPs; see e.g. EP-A-0 392225); antipathogenic substances produced by microorganisms, for examplepeptide antibiotics or heterocyclic antibiotics (see e.g. WO 95/33818)or protein or polypeptide factors involved in plant pathogen defence(so-called “plant disease resistance genes”, as described in WO03/000906).

Useful plants of elevated interest in connection with present inventionare cereals; soybean; rice; oil seed rape; pome fruits; stone fruits;peanuts; coffee; tea; strawberries; turf; vines and vegetables, such astomatoes, potatoes, cucurbits and lettuce.

The term “locus” of a useful plant as used herein is intended to embracethe place on which the useful plants are growing, where the plantpropagation materials of the useful plants are sown or where the plantpropagation materials of the useful plants will be placed into the soil.An example for such a locus is a field, on which crop plants aregrowing.

The term “plant propagation material” is understood to denote generativeparts of a plant, such as seeds, which can be used for themultiplication of the latter, and vegetative material, such as cuttingsor tubers, for example potatoes. There may be mentioned for exampleseeds (in the strict sense), roots, fruits, tubers, bulbs, rhizomes andparts of plants. Germinated plants and young plants which are to betransplanted after germination or after emergence from the soil, mayalso be mentioned. These young plants may be protected beforetransplantation by a total or partial treatment by immersion. Preferably“plant propagation material” is understood to denote seeds.

A further aspect of the instant invention is a method of protectingnatural substances of plant and/or animal origin, which have been takenfrom the natural life cycle, and/or their processed forms against attackof fungi, which comprises applying to said natural substances of plantand/or animal origin or their processed forms a combination ofcomponents (A) and (B) and (C) in a synergistically effective amount.

According to the instant invention, the term “natural substances ofplant origin, which have been taken from the natural life cycle” denotesplants or parts thereof which have been harvested from the natural lifecycle and which are in the freshly harvested form. Examples of suchnatural substances of plant origin are stalks, leafs, tubers, seeds,fruits or grains. According to the instant invention, the term“processed form of a natural substance of plant origin” is understood todenote a form of a natural substance of plant origin that is the resultof a modification process. Such modification processes can be used totransform the natural substance of plant origin in a more storable formof such a substance (a storage good). Examples of such modificationprocesses are pre-drying, moistening, crushing, comminuting, grounding,compressing or roasting. Also falling under the definition of aprocessed form of a natural substance of plant origin is timber, whetherin the form of crude timber, such as construction timber, electricitypylons and barriers, or in the form of finished articles, such asfurniture or objects made from wood.

According to the instant invention, the term “natural substances ofanimal origin, which have been taken from the natural life cycle and/ortheir processed forms” is understood to denote material of animal originsuch as skin, hides, leather, furs, hairs and the like.

The combinations according the present invention can preventdisadvantageous effects such as decay, discoloration or mold.

A preferred embodiment is a method of protecting natural substances ofplant origin, which have been taken from the natural life cycle, and/ortheir processed forms against attack of fungi, which comprises applyingto said natural substances of plant and/or animal origin or theirprocessed forms a combination of components (A) and (B) and (C) in asynergistically effective amount.

A further preferred embodiment is a method of protecting fruits,preferably pomes, stone fruits, soft fruits and citrus fruits, whichhave been taken from the natural life cycle, and/or their processedforms, which comprises applying to said fruits and/or their processedforms a combination of components (A) and (B) and (C) in asynergistically effective amount.

The combinations of the present invention may also be used in the fieldof protecting industrial material against attack of fungi. According tothe instant invention, the term “industrial material” denotes non-livematerial which have been prepared for use in industry. For example,industrial materials which are intended to be protected against attackof fungi can be glues, sizes, paper, board, textiles, carpets, leather,wood, constructions, paints, plastic articles, cooling lubricants,aquaeous hydraulic fluids and other materials which can be infestedwith, or decomposed by, microorganisms. Cooling and heating systems,ventilation and air conditioning systems and parts of production plants,for example cooling-water circuits, which may be impaired bymultiplication of microorganisms may also be mentioned from amongst thematerials to be protected. The combinations according the presentinvention can prevent disadvantageous effects such as decay,discoloration or mold.

The combinations of the present invention may also be used in the fieldof protecting technical material against attack of fungi. According tothe instant invention, the term “technical material” includes paper;carpets; constructions; cooling and heating systems; ventilation and airconditioning systems and the like. The combinations according thepresent invention can prevent disadvantageous effects such as decay,discoloration or mold.

The combinations according to the present invention are particularlyeffective against powdery mildews; rusts; leafspot species; earlyblights and molds; especially against Septoria, Puccinia, Erysiphe,Pyrenophora and Tapesia in cereals; Phakopsora in soybeans; Hemileia incoffee; Phragmidium in roses; Alternaria in potatoes, tomatoes andcucurbits; Sclerotinia in turf, vegetables, sunflower and oil seed rape;black rot, red fire, powdery mildew, grey mold and dead arm disease invine; Botrytis cinerea in fruits; Monilinia spp. in fruits andPenicillium spp. in fruits.

The combinations according to the present invention are furthermoreparticularly effective against seedborne and soilborne diseases, such asAlternaria spp., Ascochyta spp., Botrytis cinerea, Cercospora spp.,Claviceps purpurea, Cochliobolus sativus, Colletotrichum spp., Epicoccumspp., Fusarium graminearum, Fusarium moniliforme, Fusarium oxysporum,Fusarium proliferatum, Fusarium solani, Fusarium subglutinans,Gaumannomyces graminis , Helminthosporium spp., Microdochium nivale,Phoma spp., Pyrenophora graminea, Pyricularia oryzae, Rhizoctoniasolani, Rhizoctonia cerealis, Sclerotinia spp., Septoria spp.,Sphacelotheca reilliana, Tilletia spp., Typhula incarnata, Urocystisocculta, Ustilago spp. or Verticillium spp.; in particular againstpathogens of cereals, such as wheat, barley, rye or oats; maize; rice;cotton; soybean; turf; sugarbeet; oil seed rape; potatoes; pulse crops,such as peas, lentils or chickpea; and sunflower.

The combinations according to the present invention are furthermoreparticularly effective against post harvest diseasese such as Botrytiscinerea, Colletotrichum musae, Curvularia lunata, Fusarium semitecum,Geotrichum candidum, Monilinia fructicola, Monilinia fructigena,Monilinia laxa, Mucor piriformis, Penicilium italicum, Peniciliumsolitum, Penicillium digitatum or Penicillium expansum in particularagainst pathogens of fruits, such as pomefruits, for example apples andpears, stone fruits, for example peaches and plums, citrus, melons,papaya, kiwi, mango, berries, for example strawberries, avocados,pomegranates and bananas, and nuts.

The amount of a combination of the invention to be applied, will dependon various factors, such as the compounds employed; the subject of thetreatment, such as, for example plants, soil or seeds; the type oftreatment, such as, for example spraying, dusting or seed dressing; thepurpose of the treatment, such as, for example prophylactic ortherapeutic; the type of fungi to be controlled or the application time.

It has been found that the use of components (B) and (C) in combinationwith the compound of formula I surprisingly and substantially enhancethe effectiveness of the latter against fungi, and vice versa.Additionally, the method of the invention is effective against a widerspectrum of such fungi that can be combated with the active ingredientsof this method, when used solely.

The active ingredient mixture of the compounds of formula I selectedfrom table 1 and 2 with active ingredients (B+C) described abovecomprises a compound selected from table 1 and 2 and an activeingredient as described above preferably in a mixing ratio of from1000:1 to 1:1000, especially from 50:1 to 1:50, more especially in aratio of from 20:1 to 1:20, even more especially from 10:1 to 1:10, veryespecially from 5:1 and 1:5, special preference being given to a ratioof from 2:1 to 1:2, and a ratio of from 4:1 to 2:1 being likewisepreferred, above all in a ratio of 1:1, or 5:1, or 5:2, or 5:3, or 5:4,or 4:1, or 4:2, or 4:3, or 3:1, or 3:2, or 2:1, or 1:5, or 2:5, or 3:5,or 4:5, or 1:4, or 2:4, or 3:4, or 1:3, or 2:3, or 1:2, or 1:600, or1:300, or 1:150, or 1:35, or 2:35, or 4:35, or 1:75, or 2:75, or 4:75,or 1:6000, or 1:3000, or 1:1500, or 1:350, or 2:350, or 4:350, or 1:750,or 2:750, or 4:750. Those mixing ratios are understood to include, onthe one hand, ratios by weight and also, on other hand, molar ratios.

In a preferred embodiment of the invention, the ratios by weight ofcomponent (A) selected from table 1 and 2 to the mixture of components(B) and (C) are 4:1 to 1:4.

In a preferred embodiment of the invention, ratios by weight ofcomponent (B) to component (C) are from 2:1 to 1:6.

The mixtures comprising a compound of formula I selected from table 1and 2 and one or more active ingredients as described above can beapplied, for example, in a single “ready-mix” form, in a combined spraymixture composed from separate formulations of the single activeingredient components, such as a “tank-mix”, and in a combined use ofthe single active ingredients when applied in a sequential manner, i.e.one after the other with a reasonably short period, such as a few hoursor days. The order of applying the compounds of formula I selected fromtable 1 and the active ingredients as described above is not essentialfor working the present invention.

The synergistic activity of the combination is apparent from the factthat the fungicidal activity of the composition of (A)+(B)+(C) isgreater than the sum of the fungicidal activities of (the mixture ofA+B) and (C), or (the mixture of A+C) and (B) or (A) and (B) and (C).

The method of the invention comprises applying to the useful plants, thelocus thereof or propagation material thereof in admixture orseparately, a synergistically effective aggregate amount of a component(A) and a component (B) and a component (C).

Some of said combinations according to the invention have a systemicaction and can be used as foliar, soil and seed treatment fungicides.

With the combinations according to the invention it is possible toinhibit or destroy the phytopathogenic microorganisms which occur inplants or in parts of plants (fruit, blossoms, leaves, stems, tubers,roots) in different useful plants, while at the same time the parts ofplants which grow later are also protected from attack byphytopathogenic microorganisms.

The combinations of the present invention are of particular interest forcontrolling a large number of fungi in various useful plants or theirseeds, especially in field crops such as potatoes, tobacco andsugarbeets, and wheat, rye, barley, oats, rice, maize, lawns, cotton,soybeans, oil seed rape, pulse crops, sunflower, coffee, sugarcane,fruit and ornamentals in horticulture and viticulture, in vegetablessuch as cucumbers, beans and cucurbits.

The combinations according to the invention are applied by treating thefungi, the useful plants, the locus thereof, the propagation materialthereof, the natural substances of plant and/or animal origin, whichhave been taken from the natural life cycle, and/or their processedforms, or the industrial materials threatened by fungus attack with acombination of components (A) and (B) and (C), preferably in asynergistically effective amount.

The combinations according to the invention may be applied before orafter infection of the useful plants, the propagation material thereof,the natural substances of plant and/or animal origin, which have beentaken from the natural life cycle, and/or their processed forms, or theindustrial materials by the fungi.

The combinations according to the invention are particularly useful forcontrolling the following plant diseases:

Alternaria species in fruit and vegetables,

Ascochyta species in pulse crops,

Botrytis cinerea in strawberries, tomatoes, sunflower, pulse crops,vegetables and grapes,

Cercospora arachidicola in peanuts,

Cochliobolus sativus in cereals,

Colletotrichum species in pulse crops,

Erysiphe species in cereals,

Erysiphe cichoracearum and Sphaerotheca fuliginea in cucurbits,

Fusarium species in cereals and maize,

Gaumannomyces graminis in cereals and lawns,

Helminthosporium species in maize, rice and potatoes,

Hemileia vastatrix on coffee,

Microdochium species in wheat and rye,

Phakopsora species in soybean,

Puccinia species in cereals, broadleaf crops and perrenial plants,

Pseudocercosporella species in cereals,

Phragmidium mucronatum in roses,

Podosphaera species in fruits,

Pyrenophora species in barley,

Pyricularia oryzae in rice,

Ramularia collo-cygni in barley,

Rhizoctonia species in cotton, soybean, cereals, maize, potatoes, riceand lawns,

Rhynchosporium secalis in barley and rye,

Sclerotinia species in lawns, lettuce, vegetables and oil seed rape,

Septoria species in cereals, soybean and vegetables,

Sphacelotheca reilliana in maize,

Tilletia species in cereals,

Uncinula necator, Guignardia bidwellii and Phomopsis viticola in vines,

Urocystis occulta in rye,

Ustilago species in cereals and maize,

Venturia species in fruits,

Monilinia species on fruits,

Penicillium species on citrus and apples.

The combinations according to the invention are preventively and/orcuratively valuable active ingredients in the field of pest control,even at low rates of application, which have a very favorable biocidalspectrum and are well tolerated by warm-blooded species, fish andplants. The active ingredients according to the invention which arepartially known for their insecticidal action act against all orindividual developmental stages of normally sensitive, but alsoresistant, animal pests, such as insects or representatives of the orderAcarina. The insecticidal or acaricidal activity of the combinationsaccording to the invention can manifest itself directly, i.e. indestruction of the pests, which takes place either immediately or onlyafter some time has elapsed, for example during ecdysis, or indirectly,for example in a reduced oviposition and/or hatching rate, a goodactivity corresponding to a destruction rate (mortality) of at least 50to 60%.

Examples of the abovementioned animal pests are: from the order Acarina,for example,

Acarus siro, Aceria sheldoni, Aculus schlechtendali, Amblyomma spp.,Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa,Calipitrimerus spp., Chorioptes spp., Dermanyssus gallinae,Eotetranychus carpini, Eriophyes spp., Hyalomma spp., Ixodes spp.,Olygonychus pratensis, Ornithodoros spp., Panonychus spp.,Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp.,Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Tarsonemus spp.and Tetranychus spp.;

from the order Anoplura, for example,

Haematopinus spp., Linognathus spp., Pediculus spp., Pemphigus spp. andPhylloxera spp.; from the order Coleoptera, for example, Agriotes spp.,Anthonomus spp., Atomaria linearis, Chaetocnema tibialis, Cosmopolitesspp., Curculio spp., Dermestes spp., Diabrotica spp., Epilachna spp.,Eremnus spp., Leptinotarsa decemlineata, Lissorhoptrus spp., Melolonthaspp., Orycaephilus spp., Otiorhynchus spp., Phlyctinus spp., Popilliaspp., Psylliodes spp., Rhizopertha spp., Scarabeidae, Sitophilus spp.,Sitotroga spp., Tenebrio spp., Tribolium spp. and Trogoderma spp.;

from the order Diptera, for example,

Aedes spp., Antherigona soccata, Bibio hortulanus, Calliphoraerythrocephala, Ceratitis spp., Chrysomyia spp., Culex spp., Cuterebraspp., Dacus spp., Drosophila melanogaster, Fannia spp., Gastrophilusspp., Glossina spp., Hypoderma spp., Hyppobosca spp., Liriomyza spp.,Lucilia spp., Melanagromyza spp., Musca spp., Oestrus spp., Orseoliaspp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp., Rhagoletispomonella, Sciara spp., Stomoxys spp., Tabanus spp., Tannia spp. andTipula spp.;

from the order Heteroptera, for example,

Cimex spp., Distantiella theobroma, Dysdercus spp., Euchistus spp.,Eurygaster spp., Leptocorisa spp., Nezara spp., Piesma spp., Rhodniusspp., Sahlbergella singularis, Scotinophara spp. and Triatoma spp.;

from the order Homoptera, for example,

Aleurothrixus floccosus, Aleyrodes brassicae, Aonidiella spp.,Aphididae, Aphis spp., Aspidiotus spp., Bemisia tabaci, Ceroplasterspp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Coccushesperidum, Empoasca spp., Eriosoma larigerum, Erythroneura spp.,Gascardia spp., Laodelphax spp., Lecanium corni, Lepidosaphes spp.,Macrosiphus spp., Myzus spp., Nephotettix spp., Nilaparvata spp.,Parlatoria spp., Pemphigus spp., Planococcus spp., Pseudaulacaspis spp.,Pseudococcus spp., Psylla spp., Pulvinaria aethiopica, Quadraspidiotusspp., Rhopalosiphum spp., Saissetia spp., Scaphoideus spp., Schizaphisspp., Sitobion spp., Trialeurodes vaporariorum, Trioza erytreae andUnaspis citri;

from the order Hymenoptera, for example,

Acromyrmex, Atta spp., Cephus spp., Diprion spp., Diprionidae, Gilpiniapolytoma, Hoplocampa spp., Lasius spp., Monomorium pharaonis, Neodiprionspp., Solenopsis spp. and Vespa spp.; from the order Isoptera, forexample,

Reticulitermes spp.;

from the order Lepidoptera, for example, Acleris spp., Adoxophyes spp.,Aegeria spp., Agrotis spp., Alabama argillaceae, Amylois spp.,Anticarsia gemmatalis, Archips spp., Argyrotaenia spp., Autographa spp.,Busseola fusca, Cadra cautella, Carposina nipponensis, Chilo spp.,Choristoneura spp., Clysia ambiguella, Cnaphalocrocis spp., Cnephasiaspp., Cochylis spp., Coleophora spp., Crocidolomia binotalis,Cryptophlebia leucotreta, Cydia spp., Diatraea spp., Diparopsiscastanea, Earias spp., Ephestia spp., Eucosma spp., Eupoeciliaambiguella, Euproctis spp., Euxoa spp., Grapholita spp., Hedyanubiferana, Heliothis spp., Hellula undalis, Hyphantria cunea, Keiferialycopersicella, Leucoptera scitella, Lithocollethisspp., Lobesiabotrana, Lymantria spp., Lyonetia spp., Malacosoma spp., Mamestrabrassicae, Manduca sexta, Operophtera spp., Ostrinia nubilalis, Pammenespp., Pandemis spp., Panolis flammea, Pectinophora gossypiela,Phthorimaea operculella, Pieris rapae, Pieris spp., Plutella xylostella,Prays spp., Scirpophaga spp., Sesamia spp., Sparganothis spp.,Spodoptera spp., Synanthedon spp., Thaumetopoea spp., Tortrix spp.,Trichoplusia ni and Yponomeuta spp.;

from the order Mallophaga, for example,

Damalinea spp. and Trichodectes spp.;

from the order Orthoptera, for example,

Blatta spp., Blattella spp., Gryllotalpa spp., Leucophaea maderae,Locusta spp., Periplaneta spp. and Schistocerca spp.;

from the order Psocoptera, for example,

Liposcelis spp.;

from the order Siphonaptera, for example,

Ceratophyllus spp., Ctenocephalides spp. and Xenopsylla cheopis;

from the order Thysanoptera, for example,

Frankliniella spp., Hercinothrips spp., Scirtothrips aurantii,Taeniothrips spp., Thrips palmi and Thrips tabaci;

from the order Thysanura, for example,

Lepisma saccharina;

nematodes, for example root knot nematodes, stem eelworms and foliarnematodes;

especially Heterodera spp., for example Heterodera schachtii, Heterodoraavenae and Heterodora trifolii; Globodera spp., for example Globoderarostochiensis; Meloidogyne spp., for example Meloidogyne incoginita andMeloidogyne javanica; Radopholus spp., for example Radopholus similis;Pratylenchus, for example Pratylenchus neglectans and Pratylenchuspenetrans; Tylenchulus, for example Tylenchulus semipenetrans;Longidorus, Trichodorus, Xiphinema, Ditylenchus, Aphelenchoides andAnguina;

crucifer flea beetles (Phyllotreta spp.);

root maggots (Delia spp.) and

cabbage seedpod weevil (Ceutorhynchus spp.).

The combinations according to the invention can be used for controlling,i. e. containing or destroying, animal pests of the abovementioned typewhich occur on useful plants in agriculture, in horticulture and inforests, or on organs of useful plants, such as fruits, flowers,foliage, stalks, tubers or roots, and in some cases even on organs ofuseful plants which are formed at a later point in time remain protectedagainst these animal pests.

When applied to the useful plants the compound of formula I is appliedat a rate of 5 to 2000 g a.i./ha, particularly 10 to 1000 g a.i./ha,e.g. 50, 75, 100 or 200 g a.i./ha, in association with 1 to 5000 ga.i./ha, particularly 2 to 2000 g a.i./ha, e.g. 100, 250, 500, 800,1000, 1500 g a.i./ha of component (B) and (C), depending on the class ofchemical employed as component (B) and (C).

In agricultural practice the application rates of the combinationaccording to the invention depend on the type of effect desired, andtypically range from 20 to 4000 g of total combination per hectare.

When the combinations of the present invention are used for treatingseed, rates of 0.001 to 50 g of a compound of formula I per kg of seed,preferably from 0.01 to 10g per kg of seed, and 0.001 to 50 g of acompound of component (B), per kg of seed, preferably from 0.01 to 10 gper kg of seed, are generally sufficient.

The invention also provides fungicidal compositions comprising acombination of components (A) and (B) and (C) as mentioned above in asynergistically effective amount, together with an agriculturallyacceptable carrier, and optionally a surfactant. In said compositions,the weight ratio of (A) to (B+C) is preferably between 1000:1 and1:1000. In a preferred embodiment of the invention, the ratios by weightin said compositions of component (A) to the mixture of components (B)and (C) are 4:1 to 1:4. In a preferred embodiment of the invention,ratios by weight of component (B) to component (C) in said compositionsare from 2:1 to 1:6.

The compositions of the invention may be employed in any conventionalform, for example in the form of a twin pack, a powder for dry seedtreatment (DS), an emulsion for seed treatment (ES), a flowableconcentrate for seed treatment (FS), a solution for seed treatment (LS),a water dispersible powder for seed treatment (WS), a capsule suspensionfor seed treatment (CF), a gel for seed treatment (GF), an emulsionconcentrate (EC), a suspension concentrate (SC), a suspo-emulsion (SE),a capsule suspension (CS), a water dispersible granule (WG), anemulsifiable granule (EG), an emulsion, water in oil (EO), an emulsion,oil in water (EW), a micro-emulsion (ME), an oil dispersion (OD), an oilmiscible flowable (OF), an oil miscible liquid (OL), a solubleconcentrate (SL), an ultra-low volume suspension (SU), an ultra-lowvolume liquid (UL), a technical concentrate (TK), a dispersibleconcentrate (DC), a wettable powder (WP) or any technically feasibleformulation in combination with agriculturally acceptable adjuvants.

Such compositions may be produced in conventional manner, e.g. by mixingthe active ingredients with appropriate formulation inerts (diluents,solvents, fillers and optionally other formulating ingredients such assurfactants, biocides, anti-freeze, stickers, thickeners and compoundsthat provide adjuvancy effects). Also conventional slow releaseformulations may be employed where long lasting efficacy is intended.Particularly formulations to be applied in spraying forms, such as waterdispersible concentrates (e.g. EC, SC, DC, OD, SE, EW, EO and the like),wettable powders and granules, may contain surfactants such as wettingand dispersing agents and other compounds that provide adjuvancyeffects, e.g. the condensation product of formaldehyde with naphthalenesulphonate, an alkylarylsulphonate, a lignin sulphonate, a fatty alkylsulphate, and ethoxylated alkylphenol and an ethoxylated fatty alcohol.

A seed dressing formulation is applied in a manner known per se to theseeds employing the combination of the invention and a diluent insuitable seed dressing formulation form, e.g. as an aqueous suspensionor in a dry powder form having good adherence to the seeds. Such seeddressing formulations are known in the art. Seed dressing formulationsmay contain the single active ingredients or the combination of activeingredients in encapsulated form, e.g. as slow release capsules ormicrocapsules.

In general, the formulations include from 0.01 to 90% by weight ofactive agent, from 0 to 20% agriculturally acceptable surfactant and 10to 99.99% solid or liquid formulation inerts and adjuvant(s), the activeagent consisting of at least the compound of formula I together withcomponent (B) and (C), and optionally other active agents, particularlymicrobiocides or conservatives or the like. Concentrated forms ofcompositions generally contain in between about 2 and 80%, preferablybetween about 5 and 70% by weight of active agent. Application forms offormulation may for example contain from 0.01 to 20% by weight,preferably from 0.01 to 5% by weight of active agent. Whereas commercialproducts will preferably be formulated as concentrates, the end userwill normally employ diluted formulations.

The Examples which follow serve to illustrate the invention, “activeingredient” denoting a mixture of compound I and compounds of component(B+C) in a specific mixing ratio.

FORMULATION EXAMPLES

Wettable powders a) b) c) active ingredient [I:comp (B + C) = 1:3(a),25%  50% 75% 1:2(b), 1:1(c)] sodium lignosulfonate 5%  5% — sodiumlauryl sulfate 3% —  5% sodium diisobutylnaphthalenesulfonate —  6% 10%phenol polyethylene glycol ether —  2% — (7-8 mol of ethylene oxide)highly dispersed silicic acid 5% 10% 10% Kaolin 62%  27% —

The active ingredient is thoroughly mixed with the adjuvants and themixture is thoroughly ground in a suitable mill, affording wettablepowders that can be diluted with water to give suspensions of thedesired concentration.

Powders for dry seed treatment a) b) c) active ingredient [I:comp (B) =1:3(a), 25% 50% 75% 1:2(b), 1:1(c)] light mineral oil  5%  5%  5% highlydispersed silicic acid  5%  5% — Kaolin 65% 40% — Talcum — 20

The active ingredient is thoroughly mixed with the adjuvants and themixture is thoroughly ground in a suitable mill, affording powders thatcan be used directly for seed treatment.

Emulsifiable concentrate active ingredient (I:comp (B + C) = 1:6) 10%octylphenol polyethylene glycol ether 3% (4-5 mol of ethylene oxide)calcium dodecylbenzenesulfonate 3% castor oil polyglycol ether (35 molof 4% ethylene oxide) Cyclohexanone 30% xylene mixture 50%

Emulsions of any required dilution, which can be used in plantprotection, can be obtained from this concentrate by dilution withwater.

Dusts a) b) c) Active ingredient [I:comp (B + C) =  5%  6%  4% 1:6(a),1:2(b), 1:10(c)] talcum 95% — — Kaolin — 94% — mineral filler — — 96%

Ready-for-use dusts are obtained by mixing the active ingredient withthe carrier and grinding the mixture in a suitable mill. Such powderscan also be used for dry dressings for seed.

Extruder granules Active ingredient (I:comp (B + C) = 2:1) 15% sodiumlignosulfonate 2% carboxymethylcellulose 1% Kaolin 82%

The active ingredient is mixed and ground with the adjuvants, and themixture is moistened with water. The mixture is extruded and then driedin a stream of air.

Coated granules Active ingredient (I:comp (B + C) = 1:10) 8%polyethylene glycol (mol. wt. 200) 3% Kaolin 89%

The finely ground active ingredient is uniformly applied, in a mixer, tothe kaolin moistened with polyethylene glycol. Non-dusty coated granulesare obtained in this manner.

Suspension concentrate active ingredient (I:comp (B + C) = 1:8) 40%propylene glycol 10% nonylphenol polyethylene glycol ether (15 mol ofethylene oxide) 6% Sodium lignosulfonate 10% carboxymethylcellulose 1%silicone oil (in the form of a 75% emulsion in water) 1% Water 32%

The finely ground active ingredient is intimately mixed with theadjuvants, giving a suspension concentrate from which suspensions of anydesired dilution can be obtained by dilution with water. Using suchdilutions, living plants as well as plant propagation material can betreated and protected against infestation by microorganisms, byspraying, pouring or immersion.

Flowable concentrate for seed treatment active ingredient (I:comp (B +C) = 1:8) 40%  propylene glycol 5% copolymer butanol PO/EO 2%tristyrenephenole with 10-20 moles EO 2% 1,2-benzisothiazolin-3-one (inthe form of a 20% solution in 0.5%   water) monoazo-pigment calcium salt5% Silicone oil (in the form of a 75% emulsion in water) 0.2%   Water45.3%  

The finely ground active ingredient is intimately mixed with theadjuvants, giving a suspension concentrate from which suspensions of anydesired dilution can be obtained by dilution with water. Using suchdilutions, living plants as well as plant propagation material can betreated and protected against infestation by microorganisms, byspraying, pouring or immersion.

Slow Release Capsule Suspension

28 parts of a combination of the compound of formula I and a compound ofcomponents (B+C), or of each of these compounds separately, are mixedwith 2 parts of an aromatic solvent and 7 parts of toluenediisocyanate/polymethylene-polyphenylisocyanate-mixture (8:1). Thismixture is emulsified in a mixture of 1.2 parts of polyvinylalcohol,0.05 parts of a defoamer and 51.6 parts of water until the desiredparticle size is achieved. To this emulsion a mixture of 2.8 parts1,6-diaminohexane in 5.3 parts of water is added. The mixture isagitated until the polymerization reaction is completed.

The obtained capsule suspension is stabilized by adding 0.25 parts of athickener and 3 parts of a dispersing agent. The capsule suspensionformulation contains 28% of the active ingredients.

The medium capsule diameter is 8-15 microns.

The resulting formulation is applied to seeds as an aqueous suspensionin an apparatus suitable for that purpose.

BIOLOGICAL EXAMPLES

Liquid culture tests in well plates:

Mycelia fragments or conidia suspensions of a fungus, prepared eitherfreshly from liquid cultures of the fungus or from cryogenic storage,were directly mixed into nutrient broth. DMSO solutions of the testcompound (max. 10 mg/ml) was diluted with 0.025% Tween20 by factor 50and 10 μl of this solution was pipetted into a microtiter plate (96-wellformat). The nutrient broth containing the fungal spores/myceliafragments was then added to give an end concentration of the testedcompound. The test plates were incubated in the dark at 24° C. and 96%rh. The inhibition of fungal growth was determined photometrically andvisually after 2-4 days, depending on the pathosystem, and percentantifungal activity relative to the untreated check was calculated.

Alternaria solani/Liquid Culture:

Conidia of the fungus from cryogenic storage were directly mixed intonutrient broth (PDB potato dextrose broth). After placing a (DMSO)solution of test compound into a microtiter plate (96-well format), thenutrient broth containing the fungal spores was added. The test plateswere incubated at 24° C. and the inhibition of growth was determinedphotometrically and visually 2-3 day after application.

Botryotinia fuckeliana (Botrytis cinerea)/Liquid Culture:

Conidia of the fungus from cryogenic storage were directly mixed intonutrient broth (Vogels broth). After placing a (DMSO) solution of testcompound into a microtiter plate (96-well format), the nutrient brothcontaining the fungal spores was added. The test plates were incubatedat 24° C. and the inhibition of growth was determined photometricallyand visually 3 days after application.

Fusarium culmorum/Liquid Culture:

Conidia of the fungus from cryogenic storage were directly mixed intonutrient broth (PDB potato dextrose broth). After placing a (DMSO)solution of test compound into a microtiter plate (96-well format), thenutrient broth containing the fungal spores was added. The test plateswere incubated at 24° C. and the inhibition of growth was determinedphotometrically and visually 3 days after application.

Gaeumannomyces graminis/Liquid Culture:

Mycelial fragments of the fungus from cryogenic storage were directlymixed into nutrient broth (PDB potato dextrose broth). After placing a(DMSO) solution of test compound into a microtiter plate (96-wellformat), the nutrient broth containing the fungal spores was added. Thetest plates were incubated at 24° C. and the inhibition of growth wasdetermined photometrically and visually 3-4 days after application.

Monographella nivalis (Microdochium nivale)/Liquid Culture:

Conidia of the fungus from cryogenic storage were directly mixed intonutrient broth (PDB potato dextrose broth). After placing a (DMSO)solution of test compound into a microtiter plate (96-well format), thenutrient broth containing the fungal spores was added. The test plateswere incubated at 24° C. and the inhibition of growth was determinedphotometrically and visually 3-4 days after application.

Mycosphaerella graminicola (Septoria tritici)/Liquid Culture:

Conidia of the fungus from cryogenic storage were directly mixed intonutrient broth (PDB potato dextrose broth). After placing a (DMSO)solution of test compound into a microtiter plate (96-well format), thenutrient broth containing the fungal spores was added. The test plateswere incubated at 24° C. and the inhibition of growth was determinedphotometrically and visually 4 days after application.

Thanatephorus cucumeris (Rhizoctonia solani)/Liquid Culture:

Mycelia fragments of a newly grown liquid culture of the fungus weredirectly mixed into nutrient broth (PDB potato dextrose broth). Afterplacing a (DMSO) solution of the test compounds into a microtiter plate(96-well format), the nutrient broth containing the fungal material wasadded. The test plates were incubated at 24° C. and the inhibition ofgrowth was determined photometrically and visually 3-4 days afterapplication.

The results are shown in the following tables.

TABLE B1 The abbreviations are defined as follows: 1.001 = compound No.1.001 STL = compound of formula VII IZM = isopyrazam Solution of STL +exp. Solution of 1.001 IZM (1:2) observed action ppm ppm ppm % activity(colby) B1.1: Gaeumannomyces graminis: 0.2000 7 0.0165 0.0335 73 0.20000.0165 0.0335 100 75 B1.2: Alternaria solani: 0.0008 4 0.0016 32 0.001632 0.0031 64 0.0001 0.0003 0 0.0003 0.0005 0 0.0005 0.0010 0 0.00100.0021 0 0.0021 0.0042 0 0.0041 0.0084 22 0.0008 0.0001 0.0003 20 40.0008 0.0010 0.0021 49 4 0.0016 0.0001 0.0003 44 32 0.0016 0.00030.0005 46 32 0.0016 0.0005 0.0010 61 32 0.0016 0.0010 0.0021 49 320.0016 0.0021 0.0042 72 32 0.0031 0.0005 0.0010 71 64 0.0031 0.00100.0021 75 64 0.0031 0.0021 0.0042 78 64 0.0031 0.0041 0.0084 87 72 B1.3:Monographella nivalis: 0.0125 0 0.0250 5 0.0500 45 0.2000 78 0.00830.0168 0 0.0165 0.0335 1 0.0330 0.0670 34 0.0125 0.0165 0.0335 30 10.0250 0.0165 0.0335 41 6 0.0250 0.0330 0.0670 83 37 0.0500 0.00830.0168 59 45 0.0500 0.0165 0.0335 53 46 0.0500 0.0330 0.0670 75 640.2000 0.0165 0.0335 87 79 B1.4: Rhizoctonia solani: 0.0125 0 0.0250 60.1000 0 0.0083 0.0168 1 0.0165 0.0335 88 0.0125 0.0165 0.0335 100 880.0250 0.0083 0.0168 59 7 0.0250 0.0165 0.0335 100 89 0.1000 0.00830.0168 51 1 B1.5: Septoria tritici: 0.0016 52 0.0010 0.0021 5 0.00210.0042 2 0.0016 0.0010 0.0021 79 55 0.0016 0.0021 0.0042 71 53

TABLE B2 The abbreviations are defined as follows: 1.001 = compound No.1.001 STL = compound of formula VII DFZ = difenoconazole Solution ofSTL + observed expected Solution of 1.001 DFZ (3:5) % action ppm ppm ppmactivity (colby) B2.1: Gaeumannomyces graminis 0.0125 0 0.0250 4 0.05000 0.1000 0 0.0188 0.0313 44 0.0125 0.0188 0.0313 89 44 0.0250 0.01880.0313 71 46 0.0500 0.0188 0.0313 64 44 0.1000 0.0188 0.0313 49 44 B2.2:Alternaria solani: 0.0016 39 0.0001 0.0002 0 0.0003 0.0005 1 0.00120.0020 4 0.0023 0.0039 1 0.0016 0.0001 0.0002 50 39 0.0016 0.0003 0.000548 39 0.0016 0.0012 0.0020 65 41 0.0016 0.0023 0.0039 66 39 B2.3:Monographella nivalis: 0.0250 0 0.0500 26 0.0047 0.0078 9 0.0094 0.01562 0.0188 0.0313 12 0.0375 0.0625 25 0.0250 0.0375 0.0625 81 25 0.05000.0047 0.0078 72 33 0.0500 0.0094 0.0156 65 27 0.0500 0.0188 0.0313 4235 0.0500 0.0375 0.0625 78 45

TABLE B3 The abbreviations are defined as follows: 1.001 = compound No.1.001 STL = compound of formula VII AZ = azoxystrobin Solution of STL +observed expected Solution of 1.001 AZ (1:2) % action ppm ppm ppmactivity (colby) B3.1: Gaeumannomyces graminis 0.0031 0 0.0063 0 0.01258 0.0250 0 0.0500 0 0.0021 0.0042 12 0.0041 0.0084 42 0.0031 0.00410.0084 91 42 0.0063 0.0021 0.0042 38 12 0.0063 0.0041 0.0084 62 420.0125 0.0041 0.0084 90 47 0.0250 0.0021 0.0042 45 12 0.0250 0.00410.0084 93 42 0.0500 0.0041 0.0084 84 42 B3.2: Alternaria solani: 0.001645 0.0031 66 0.0003 0.0005 3 0.0005 0.0010 0 0.0010 0.0021 0 0.00160.0003 0.0005 67 47 0.0016 0.0010 0.0021 72 45 0.0031 0.0005 0.0010 8166 B3.3: Fusarium culmorum: 0.0250 19 0.0500 48 0.1000 55 0.2000 590.0165 0.0335 6 0.0330 0.0670 0 0.0660 0.1340 0 0.0660 0.1340 0 0.02500.0165 0.0335 30 24 0.0500 0.0330 0.0670 56 48 0.0500 0.0660 0.1340 6248 0.1000 0.0660 0.1340 63 55 0.2000 0.0660 0.1340 69 59 B3.4:Monographella nivalis: 0.0008 1 0.0010 0.0021 60 0.0008 0.0010 0.0021 7761 B3.5: Septoria tritici: 0.0016 42 0.0031 83 0.0010 0.0021 0 0.00210.0042 4 0.0041 0.0084 17 0.0016 0.0010 0.0021 49 42 0.0016 0.00210.0042 65 45 0.0031 0.0041 0.0084 94 86

TABLE B4 The abbreviations are defined as follows: 1.001 = compound No.1.001 STL = compound of formula VII PTC = prothioconazole Solution ofSTL + PTC expected Solution of (1:2) observed % action 1.001 ppm ppm ppmactivity (colby) B4.1: Gaeumannomyces graminis 0.0125 0 0.0250 0 0.05000 0.1000 0 0.2000 12 0.0165 0.0335 24 0.0330 0.0670 88 0.0125 0.01650.0335 79 24 0.0250 0.0330 0.0670 100 88 0.0500 0.0165 0.0335 88 240.1000 0.0165 0.0335 62 24 0.2000 0.0165 0.0335 74 33 B4.2: Alternariasolani: 0.0008 29 0.0016 47 0.0031 73 0.0001 0.0003 0 0.0010 0.0021 00.0021 0.0042 0 0.0041 0.0084 3 0.0008 0.0010 0.0021 42 29 0.0016 0.00010.0003 63 47 0.0016 0.0021 0.0042 64 47 0.0031 0.0041 0.0084 86 74 B4.3:Monographella nivalis: 0.0500 15 0.1000 64 0.0083 0.0168 4 0.0165 0.03350 0.0500 0.0165 0.0335 83 15 0.1000 0.0083 0.0168 79 65

TABLE B5 The abbreviations are defined as follows: 1.001 = compound No.1.001 STL = compound of formula VII TCZ = tebuconazole Solution of STL +TCZ expected Solution of (1:2) observed % action 1.001 ppm ppm ppmactivity (colby) B5.1: Gaeumannomyces graminis 0.0250 0 0.0500 2 0.10000 0.2000 0 0.0165 0.0335 42 0.0330 0.0670 78 0.0250 0.0165 0.0335 57 420.0250 0.0330 0.0670 100 78 0.0500 0.0330 0.0670 98 78 0.1000 0.01650.0335 61 42 0.1000 0.0330 0.0670 98 78 0.2000 0.0165 0.0335 68 420.2000 0.0330 0.0670 89 78 B5.2: Alternaria solani: 0.0008 3 0.0016 360.0031 75 0.0005 0.0010 0 0.0010 0.0021 0 0.0021 0.0042 0 0.0008 0.00050.0010 31 3 0.0016 0.0010 0.0021 44 36 0.0016 0.0021 0.0042 64 36 0.00310.0010 0.0021 86 75 B5.3: Fusarium culmorum: 0.0250 9 0.0500 39 0.00210.0042 2 0.0041 0.0084 1 0.0083 0.0168 4 0.0250 0.0021 0.0042 32 110.0250 0.0041 0.0084 28 11 0.0500 0.0041 0.0084 52 40 0.0500 0.00830.0168 52 41 B5.4: Monographella nivalis: 0.0250 2 0.0500 9 0.1000 600.0083 0.0168 0 0.0165 0.0335 5 0.0330 0.0670 14 0.0660 0.1340 63 0.02500.0165 0.0335 25 7 0.0250 0.0330 0.0670 53 16 0.0500 0.0083 0.0168 29 90.0500 0.0165 0.0335 41 13 0.0500 0.0330 0.0670 65 22 0.0500 0.06600.1340 84 66 0.1000 0.0083 0.0168 70 60 0.1000 0.0165 0.0335 76 620.1000 0.0330 0.0670 85 66 B5.5: Rhizoctonia solani: 0.0250 13 0.0500 10.1000 17 0.0330 0.0670 0 0.0660 0.1340 28 0.0250 0.0330 0.0670 97 130.0500 0.0660 0.1340 87 29 0.1000 0.0660 0.1340 61 41 B5.6: Septoriatritici: 0.0008 27 0.0016 45 0.0031 82 0.0010 0.0021 0 0.0021 0.0042 50.0041 0.0084 0 0.0008 0.0010 0.0021 36 27 0.0016 0.0010 0.0021 70 450.0016 0.0021 0.0042 60 47 0.0031 0.0041 0.0084 91 82

TABLE B6 The abbreviations are defined as follows: 1.001 = compound No.1.001 STL = compound of formula VII PYS = pyraclostrobin Solution ofSTL + PYS expected Solution of (1:1) observed % action 1.001 ppm ppm ppmactivity (colby) B6.1: Gaeumannomyces graminis 0.0063 0 0.0250 0 0.10000 0.0125 0.0125 15 0.0063 0.0125 0.0125 34 15 0.0250 0.0125 0.0125 46 150.1000 0.0125 0.0125 84 15 B6.2: Alternaria solani: 0.0016 35 0.0031 710.0002 0.0002 0 0.0031 0.0031 0 0.0063 0.0063 0 0.0016 0.0002 0.0002 4535 0.0016 0.0031 0.0031 46 35 0.0031 0.0063 0.0063 80 71 B6.3:Monographella nivalis: 0.0016 0 0.0031 3 0.0031 0.0031 4 0.0063 0.006378 0.0016 0.0031 0.0031 28 4 0.0031 0.0063 0.0063 92 78 B6.4: Septoriatritici: 0.0008 11 0.0016 53 0.0031 89 0.0002 0.0002 3 0.0016 0.0016 30.0031 0.0031 2 0.0063 0.0063 1 0.0008 0.0016 0.0016 28 14 0.0016 0.00020.0002 66 54 0.0016 0.0031 0.0031 69 54 0.0031 0.0063 0.0063 97 89

TABLE B7 The abbreviations are defined as follows: 1.001 = compound No.1.001 STL = compound of formula VII TFS = trifloxystrobin Solution ofSTL + TFS observed expected Solution of (1:1) % action 1.001 ppm ppm ppmactivity (colby) B7.1: Gaeumannomyces graminis 0.0063 0 0.0125 4 0.02502 0.0500 3 0.1000 0 0.2000 0 0.0125 0.0125 19 0.0250 0.0250 53 0.00630.0125 0.0125 71 19 0.0125 0.0250 0.0250 92 55 0.0250 0.0250 0.0250 9054 0.0500 0.0125 0.0125 44 21 0.0500 0.0250 0.0250 74 55 0.1000 0.02500.0250 92 53 0.2000 0.0250 0.0250 92 53 B7.2: Alternaria solani: 0.001628 0.0031 66 0.0002 0.0002 4 0.0004 0.0004 0 0.0016 0.0016 0 0.00310.0031 0 0.0063 0.0063 5 0.0016 0.0002 0.0002 41 31 0.0016 0.0004 0.000442 28 0.0016 0.0016 0.0016 43 28 0.0016 0.0031 0.0031 57 28 0.00310.0004 0.0004 75 66 0.0031 0.0031 0.0031 76 66 0.0031 0.0063 0.0063 8168 B7.3: Fusarium culmorum: 0.0125 11 0.0250 24 0.0500 49 0.1000 580.2000 60 0.0031 0.0031 2 0.0063 0.0063 0 0.0125 0.0125 1 0.0250 0.02509 0.0500 0.0500 5 0.1000 0.1000 10 0.0125 0.0250 0.0250 47 18 0.02500.0031 0.0031 38 25 0.0250 0.0063 0.0063 36 24 0.0250 0.0125 0.0125 3524 0.0250 0.0250 0.0250 62 30 0.0250 0.0500 0.0500 69 28 0.0500 0.00630.0063 54 49 0.0500 0.0125 0.0125 62 49 0.0500 0.0250 0.0250 69 530.0500 0.0500 0.0500 77 52 0.0500 0.1000 0.1000 81 54 0.1000 0.01250.0125 65 58 0.1000 0.0250 0.0250 71 61 0.1000 0.0500 0.0500 75 600.1000 0.1000 0.1000 82 62 0.2000 0.0250 0.0250 75 63 0.2000 0.05000.0500 76 62 0.2000 0.1000 0.1000 83 64 B7.4: Rhizoctonia solani: 0.01253 0.0250 8 0.0125 0.0125 0 0.0125 0.0125 0.0125 96 3 0.0250 0.01250.0125 100 8 B7.5: Septoria tritici: 0.0016 53 0.0031 0.0031 42 0.00160.0031 0.0031 89 72

TABLE B8 The abbreviations are defined as follows: 1.001 = compound No.1.001 STL = compound of formula VII FDL = fludioxonil Solution of STL +FDL observed expected Solution of (1:4) % action 1.001 ppm ppm ppmactivity (colby) B8.1: Gaeumannomyces graminis 0.0250 0 0.0500 0 0.10000 0.2000 0 0.0100 0.0400 16 0.0200 0.0800 52 0.0250 0.0200 0.0800 100 520.0500 0.0200 0.0800 100 52 0.1000 0.0200 0.0800 100 52 0.2000 0.01000.0400 61 16 0.2000 0.0200 0.0800 96 52 B8.2: Alternaria solani: 0.000819 0.0016 42 0.0031 68 0.0006 0.0025 0 0.0013 0.0050 0 0.0025 0.0100 00.0008 0.0006 0.0025 40 19 0.0016 0.0013 0.0050 60 42 0.0031 0.00250.0100 80 68 B8.3: Fusarium culmorum: 0.0250 18 0.0500 51 0.2000 550.0100 0.0400 9 0.0200 0.0800 15 0.0250 0.0100 0.0400 42 25 0.02500.0200 0.0800 76 30 0.0500 0.0200 0.0800 91 58 0.2000 0.0200 0.0800 7162

TABLE B9 The abbreviations are defined as follows: 1.001 = compound No.1.001 STL = compound of formula VII CPL = cyprodinil Solution of STL +CPL observed expected Solution of (1:4) % action 1.001 ppm ppm ppmactivity (colby) B9.1: Gaeumannomyces graminis 0.0125 0 0.0250 0 0.05000 0.1000 0 0.2000 0 0.0100 0.0400 0 0.0200 0.0800 30 0.0125 0.01000.0400 39 0 0.0250 0.0200 0.0800 88 30 0.0500 0.0200 0.0800 56 30 0.10000.0200 0.0800 55 30 0.2000 0.0200 0.0800 66 30 B9.2: Alternaria solani:0.0016 37 0.0031 67 0.0002 0.0006 0 0.0013 0.0050 0 0.0025 0.0100 00.0016 0.0002 0.0006 41 37 0.0016 0.0013 0.0050 43 37 0.0031 0.00250.0100 75 67 B9.3: Rhizoctonia solani: 0.0500 0 0.2000 6 0.0200 0.0800 00.0500 0.0200 0.0800 99 0 0.2000 0.0200 0.0800 69 6

TABLE B10 The abbreviations are defined as follows: 1.001 = compound No.1.001 STL = compound of formula VII FLN = fluazinam Solution of STL +FLN observed expected Solution of (1:6) % action 1.001 ppm ppm ppmactivity (colby) B10.1: Gaeumannomyces graminis 0.0125 0 0.0250 0 0.05000 0.1000 0 0.2000 0 0.0036 0.0214 3 0.0072 0.0428 40 0.0143 0.0857 910.0286 0.1714 90 0.0125 0.0072 0.0428 83 40 0.0250 0.0072 0.0428 89 400.0250 0.0143 0.0857 100 91 0.0500 0.0286 0.1714 100 90 0.1000 0.00360.0214 51 3 0.1000 0.0286 0.1714 100 90 0.2000 0.0072 0.0428 76 40B10.2: Alternaria solani: 0.0016 38 0.0001 0.0003 0 0.0009 0.0054 00.0016 0.0001 0.0003 55 38 0.0016 0.0009 0.0054 52 38 B10.3:Monographella nivalis: 0.0063 0 0.0125 0 0.0250 0 0.0500 16 0.1000 610.2000 85 0.0036 0.0214 8 0.0072 0.0428 37 0.0063 0.0036 0.0214 26 80.0125 0.0072 0.0428 98 37 0.0250 0.0072 0.0428 95 38 0.0500 0.00720.0428 84 47 0.1000 0.0036 0.0214 82 64 0.1000 0.0072 0.0428 94 760.2000 0.0072 0.0428 100 90 B10.4: Rhizoctonia solani: 0.0250 0 0.0500 00.0143 0.0857 0 0.0250 0.0143 0.0857 100 0 0.0500 0.0143 0.0857 71 0

TABLE B11 The abbreviations are defined as follows: 1.001 = compound No.1.001 IZM = isopyrazam DFZ: difenoconazole Solution of observed expectedSolution of IZM + DFZ (1:1) % action 1.001 ppm ppm ppm activity (colby)B11.1: Gaeumannomyces graminis: 0.1000 0 0.0500 0.0500 0 0.1000 0.05000.0500 57 0 B11.2: Alternaria solani: 0.0008 24 0.0016 48 0.0016 0.001610 0.0031 0.0031 9 0.0008 0.0016 0.0016 45 31 0.0016 0.0031 0.0031 63 53B11.3: Monographella nivalis: 0.0500 36 0.1000 69 0.0063 0.0063 0 0.01250.0125 0 0.1000 0.1000 2 0.0500 0.0063 0.0063 54 36 0.1000 0.0125 0.012582 69 0.1000 0.1000 0.1000 89 70 B11.4: Rhizoctonia solani: 0.0125 00.0250 8 0.0500 0 0.2000 0 0.0250 0.0250 17 0.0500 0.0500 36 0.01250.0250 0.0250 37 17 0.0250 0.0500 0.0500 52 41 0.0500 0.0500 0.0500 7236 0.2000 0.0250 0.0250 44 17 0.2000 0.0500 0.0500 56 36

TABLE B12 The abbreviations are defined as follows: 1.001 = compound No.1.001 IZM = isopyrazam AZO: azoxystrobin Solution of IZM + AZO expectedSolution of (1:1) observed action 1.001 ppm ppm ppm % activity (colby)B12.1: Gaeumannomyces graminis: 0.0016 0 0.0031 0 0.0063 0 0.0125 00.0031 0.0031 45 0.0016 0.0031 0.0031 79 45 0.0031 0.0031 0.0031 92 450.0063 0.0031 0.0031 68 45 0.0125 0.0031 0.0031 80 45 B12.2: Alternariasolani: 0.0008 33 0.0016 46 0.0002 0.0002 5 0.0016 0.0016 8 0.00310.0031 14 0.0008 0.0016 0.0016 58 38 0.0016 0.0002 0.0002 78 48 0.00160.0031 0.0031 77 53 B12.3: Monographella nivalis: 0.0031 1 0.0063 10.0250 0 0.0500 29 0.0063 0.0063 79 0.0031 0.0063 0.0063 100 79 0.00630.0063 0.0063 93 79 0.0250 0.0063 0.0063 100 79 0.0500 0.0063 0.0063 9885 B12.4: Rhizoctonia solani: 0.0063 0 0.0125 0 0.0250 0 0.0500 0 0.10003 0.2000 17 0.0125 0.0125 54 0.0250 0.0250 69 0.0500 0.0500 85 0.00630.0125 0.0125 91 54 0.0125 0.0250 0.0250 88 69 0.0250 0.0250 0.0250 9669 0.0250 0.0500 0.0500 100 85 0.0500 0.0125 0.0125 60 54 0.0500 0.02500.0250 76 69 0.0500 0.0500 0.0500 95 85 0.1000 0.0250 0.0250 84 700.1000 0.0500 0.0500 100 85 0.2000 0.0250 0.0250 87 74 0.2000 0.05000.0500 99 87

TABLE B13 The abbreviations are defined as follows: 1.001 = compound No.1.001 IZM = isopyrazam PTC: prothioconazole Solution of IZM + PTCexpected Solution of (1:1) observed action 1.001 ppm ppm ppm % activity(colby) B13.1: Alternaria solani: 0.0008 20 0.0016 51 0.0031 78 0.00040.0004 16 0.0008 0.0008 5 0.0016 0.0016 10 0.0031 0.0031 12 0.00080.0004 0.0004 45 32 0.0008 0.0008 0.0008 48 23 0.0008 0.0016 0.0016 6027 0.0016 0.0016 0.0016 65 56 0.0016 0.0031 0.0031 65 57 0.0031 0.00040.0004 96 82 B13.2: Monographella nivalis: 0.0250 8 0.1000 61 0.01250.0125 0 0.0500 0.0500 21 0.0250 0.0500 0.0500 51 27 0.1000 0.01250.0125 87 61 B13.3: Rhizoctonia solani: 0.0250 0 0.0500 0 0.2000 00.0500 0.0500 37 0.0250 0.0500 0.0500 55 37 0.0500 0.0500 0.0500 58 370.2000 0.0500 0.0500 61 37

TABLE B14 The abbreviations are defined as follows: 1.001 = compound No.1.001 IZM = isopyrazam TCZ: tebuconazole Solution of IZM + TCZ expectedSolution of 1.001 (1:1) observed action ppm ppm ppm % activity (colby)B14.1: Gaeumannomyces graminis: 0.1000 12 0.2000 0 0.1000 0.1000 00.1000 0.1000 51 0.1000 0.1000 0.1000 76 57 0.2000 0.1000 0.1000 100 51B14.2: Alternaria solani: 0.0004 9 0.0008 24 0.0016 52 0.0031 83 0.00020.0002 7 0.0004 0.0004 7 0.0008 0.0008 9 0.0016 0.0016 6 0.0031 0.003117 0.0004 0.0004 0.0004 24 15 0.0008 0.0008 0.0008 37 31 0.0008 0.00160.0016 49 29 0.0016 0.0002 0.0002 73 56 0.0016 0.0016 0.0016 62 550.0016 0.0031 0.0031 80 61 0.0031 0.0004 0.0004 94 84 B14.3:Monographella nivalis: 0.0500 17 0.1000 67 0.0063 0.0063 0 0.0125 0.01250 0.0500 0.0063 0.0063 34 17 0.1000 0.0125 0.0125 81 67 B14.4:Rhizoctonia solani: 0.0125 0 0.0250 0 0.0500 3 0.1000 7 0.0250 0.0250 280.0500 0.0500 76 0.1000 0.1000 78 0.0125 0.0250 0.0250 57 28 0.02500.0500 0.0500 87 76 0.0500 0.1000 0.1000 97 78 0.1000 0.1000 0.1000 8979

TABLE B15 The abbreviations are defined as follows: 1.001 = compound No.1.001 IZM = isopyrazam PYS: pyraclostrobin Solution of IZM + PYSexpected Solution of 1.001 (2:1) observed action ppm ppm ppm % activity(colby) B15.1: Alternaria solani: 0.0008 36 0.0016 56 0.0031 82 0.00050.0003 2 0.0010 0.0005 11 0.0021 0.0010 0 0.0042 0.0021 10 0.0008 0.00210.0010 65 36 0.0016 0.0005 0.0003 79 57 0.0016 0.0010 0.0005 79 610.0016 0.0021 0.0010 78 56 0.0016 0.0042 0.0021 82 60 0.0031 0.00420.0021 94 84 B15.2: Monographella nivalis: 0.0500 17 0.1000 63 0.01680.0083 27 0.0500 0.0168 0.0083 54 40 0.1000 0.0168 0.0083 94 73 B15.3:Rhizoctonia solani: 0.0031 5 0.0063 0 0.0125 0 0.0250 0 0.0500 9 0.00840.0041 11 0.0168 0.0083 58 0.0031 0.0084 0.0041 37 15 0.0063 0.00840.0041 49 11 0.0063 0.0168 0.0083 72 58 0.0125 0.0084 0.0041 43 110.0125 0.0168 0.0083 87 58 0.0250 0.0084 0.0041 50 11 0.0250 0.01680.0083 72 58 0.0500 0.0084 0.0041 40 19 0.0500 0.0168 0.0083 77 62

TABLE B16 The abbreviations are defined as follows: 1.001 = compound No.1.001 IZM = isopyrazam TFS: trifloxystrobin Solution of expectedSolution of 1.001 IZM + TFS (2:1) observed action ppm ppm ppm % activity(colby) B16.1: Gaeumannomyces graminis: 0.2000 16 0.0670 0.0330 140.1340 0.0660 14 0.2000 0.0670 0.0330 75 28 0.2000 0.1340 0.0660 85 60B16.2: Alternaria solani: 0.0008 40 0.0005 0.0003 0 0.0010 0.0005 00.0021 0.0010 12 0.0008 0.0005 0.0003 50 40 0.0008 0.0010 0.0005 52 400.0008 0.0021 0.0010 60 47 B16.3: Fusarium culmorum: 0.0250 26 0.0500 460.1000 50 0.2000 56 0.0084 0.0041 6 0.0335 0.0165 9 0.0670 0.0330 40.1340 0.0660 4 0.1340 0.0660 2 0.0250 0.0084 0.0041 41 30 0.0250 0.03350.0165 46 32 0.0250 0.0670 0.0330 68 28 0.0500 0.0335 0.0165 58 510.0500 0.0670 0.0330 70 48 0.0500 0.1340 0.0660 78 47 0.1000 0.06700.0330 62 52 0.1000 0.1340 0.0660 77 51 0.2000 0.0335 0.0165 67 600.2000 0.0670 0.0330 66 57 0.2000 0.1340 0.0660 75 57 B16.4:Monographella nivalis: 0.0004 2 0.0010 0.0005 42 0.0004 0.0010 0.0005 6444 B16.5: Rhizoctonia solani: 0.0063 0 0.0125 0 0.0250 0 0.0500 110.1000 0 0.0084 0.0041 0 0.0168 0.0083 3 0.0063 0.0168 0.0083 88 30.0125 0.0084 0.0041 35 0 0.0250 0.0168 0.0083 74 3 0.0500 0.0168 0.008345 14 0.1000 0.0168 0.0083 64 3

TABLE B17 The abbreviations are defined as follows: 1.001 = compound No.1.001 IZM = isopyrazam FDL: fludioxonil Solution of IZM + FDL expectedSolution of 1.001 (1:2) observed action ppm ppm ppm % activity (colby)B17.1: Alternaria solani 0.0008 25 0.0016 57 0.0001 0.0003 0 0.00030.0005 9 0.0010 0.0021 1 0.0021 0.0042 0 0.0008 0.0001 0.0003 49 250.0008 0.0003 0.0005 42 32 0.0008 0.0010 0.0021 44 26 0.0016 0.00010.0003 79 57 0.0016 0.0010 0.0021 78 57 0.0016 0.0021 0.0042 76 57B17.2: Fusarium culmorum: 0.0063 9 0.0125 16 0.0250 27 0.0500 46 0.200054 0.0041 0.0084 3 0.0083 0.0168 6 0.0165 0.0335 0 0.0330 0.0670 20.0660 0.1340 2 0.0660 0.1340 48 0.0063 0.0083 0.0168 48 15 0.01250.0165 0.0335 28 16 0.0250 0.0165 0.0335 96 27 0.0250 0.0330 0.0670 6028 0.0500 0.0041 0.0084 55 48 0.0500 0.0330 0.0670 79 47 0.0500 0.06600.1340 100 72 0.2000 0.0660 0.1340 100 76 B17.3: Monographella nivalis:0.1000 73 0.0083 0.0168 0 0.1000 0.0083 0.0168 80 73 B17.4: Rhizoctoniasolani: 0.0250 0 0.0500 6 0.1000 0 0.0330 0.0670 81 0.0250 0.0330 0.067096 81 0.0500 0.0330 0.0670 96 82 0.1000 0.0330 0.0670 96 81

TABLE B18 The abbreviations are defined as follows: 1.001 = compound No.1.001 IZM = isopyrazam CPL: cyprodinil Solution of IZM + CPL expectedSolution of 1.001 (1:2) observed action ppm ppm ppm % activity (colby)B18.1: Alternaria solani 0.0016 60 0.0001 0.0003 12 0.0003 0.0005 10.0010 0.0021 1 0.0021 0.0042 8 0.0016 0.0001 0.0003 73 65 0.0016 0.00030.0005 67 61 0.0016 0.0010 0.0021 68 60 0.0016 0.0021 0.0042 72 63B18.2: Monographella nivalis: 0.0031 0 0.0063 0 0.0041 0.0084 24 0.00310.0041 0.0084 78 24 0.0063 0.0041 0.0084 51 24 B18.3: Rhizoctoniasolani: 0.0125 20 0.0250 0 0.0500 0 0.0165 0.0335 47 0.0125 0.01650.0335 77 58 0.0250 0.0165 0.0335 71 47 0.0500 0.0165 0.0335 54 47B18.4: Septoria tritici: 0.0016 62 0.0001 0.0003 0 0.0016 0.0001 0.000369 62

TABLE B19 The abbreviations are defined as follows: 1.001 = compound No.1.001 IZM = isopyrazam FLN: fluazinam Solution of IZM + FLN expectedSolution of 1.001 (1:3) observed action ppm ppm ppm % activity (colby)B19.1: Gaeumannomyces graminis: 0.0500 0 0.1000 1 0.2000 0 0.0500 0.150076 0.0500 0.1500 30 0.0500 0.0500 0.1500 95 30 0.1000 0.0500 0.1500 8331 0.2000 0.0500 0.1500 90 30 B19.2: Alternaria solani: 0.0004 11 0.000829 0.0016 65 0.0001 0.0003 5 0.0002 0.0006 0 0.0004 0.0012 16 0.00080.0023 16 0.0016 0.0047 10 0.0004 0.0001 0.0003 28 15 0.0008 0.00010.0003 47 33 0.0008 0.0004 0.0012 46 40 0.0008 0.0008 0.0023 46 400.0016 0.0002 0.0006 72 65 0.0016 0.0016 0.0047 78 69 B19.3:Monographella nivalis: 0.0250 3 0.0500 12 0.1000 63 0.2000 90 0.00630.0188 3 0.0250 0.0750 8 0.0250 0.0250 0.0750 95 10 0.0500 0.0250 0.075055 19 0.1000 0.0063 0.0188 80 65 0.1000 0.0250 0.0750 92 66 0.20000.0250 0.0750 100 90

TABLE B20 The abbreviations are defined as follows: 1.001 = compound No.1.001 DFZ = difenoconazole AZO: azoxystrobin Solution of DFZ + AZOexpected Solution of 1.001 (1:1) observed action ppm ppm ppm % activity(colby) B20.1: Gaeumannomyces graminis: 0.0125 0 0.0250 0 0.0500 00.2000 0 0.0125 0.0125 54 0.0250 0.0250 42 0.0125 0.0125 0.0125 60 540.0125 0.0250 0.0250 72 42 0.0250 0.0250 0.0250 76 42 0.0500 0.02500.0250 79 42 0.2000 0.0250 0.0250 63 42 B20.2: Monographella nivalis:0.0500 6 0.0063 0.0063 39 0.0500 0.0063 0.0063 79 42 B20.3: Rhizoctoniasolani: 0.0500 0 0.0500 0.0500 33 0.0500 0.0500 0.0500 52 33 B20.4:Septoria tritici: 0.0016 35 0.0004 0.0004 5 0.0016 0.0004 0.0004 47 38

TABLE B21 The abbreviations are defined as follows: 1.001 = compound No.1.001 DFZ = difenoconazole PTC = prothioconazole B21.1: Rhizoctoniasolani: Solution of DFZ + PTC expected Solution of 1.001 (1:1) observedaction ppm ppm ppm % activity (colby) 0.0500 0 0.1000 0.1000 15 0.05000.1000 0.1000 52 15

TABLE B22 The abbreviations are defined as follows: 1.001 = compound No.1.001 DFZ = difenoconazole TCZ = tebuconazole B22.1: Monographellanivalis: Solution of DFZ + TCZ expected Solution of 1.001 (1:1) observedaction ppm ppm ppm % activity (colby) 0.1000 46 0.0125 0.0125 1 0.10000.0125 0.0125 59 46

TABLE B23 The abbreviations are defined as follows: 1.001 = compound No.1.001 DFZ = difenoconazole PYS = pyraclostrobin B23.1: Monographellanivalis: Solution of DFZ + PYS expected Solution of 1.001 (2:1) observed% action ppm ppm ppm activity (colby) 0.0250 0 0.0500 6 0.0670 0.0330 580.0250 0.0670 0.0330 85 58 0.0500 0.0670 0.0330 87 61

TABLE B24 The abbreviations are defined as follows: 1.001 = compound No.1.001 DFZ = difenoconazole TFS = trifloxystrobin Solution of DFZ + TFSexpected Solution of 1.001 (2:1) observed action ppm ppm ppm % activity(colby) B24.1: Alternaria solani 0.0016 40 0.0003 0.0001 0 0.0016 0.00030.0001 66 40 B24.2: Monographella nivalis: 0.0008 0 0.0016 0 0.0031 00.0063 0 0.0010 0.0005 15 0.0021 0.0010 49 0.0042 0.0021 79 0.00080.0010 0.0005 27 15 0.0016 0.0021 0.0010 64 49 0.0016 0.0042 0.0021 9279 0.0031 0.0042 0.0021 90 79 0.0063 0.0042 0.0021 94 79 B24.3: Botrytiscinerea: 0.0063 69 0.0125 83 0.0168 0.0083 24 0.0063 0.0168 0.0083 85 770.0125 0.0168 0.0083 98 87

TABLE B25 The abbreviations are defined as follows: 1.001 = compound No.1.001 DFZ = difenoconazole FDL = Fludioxonil Solution of DFZ + FDLexpected Solution of 1.001 (1:2) observed % action ppm ppm ppm activity(colby) B25.1: Fusarium culmorum 0.0250 27 0.0500 50 0.0165 0.0335 80.0330 0.0670 10 0.0660 0.1340 75 0.0250 0.0165 0.0335 51 33 0.05000.0330 0.0670 88 55 0.0500 0.0660 0.1340 99 87 B25.2. Botrytis cinera0.0031 54 0.0063 69 0.0125 84 0.0041 0.0084 11 0.0083 0.0168 22 0.00310.0041 0.0084 65 59 0.0063 0.0041 0.0084 91 72 0.0063 0.0083 0.0168 10076 0.0125 0.0041 0.0084 96 86 0.0125 0.0083 0.0168 100 88

TABLE B26 The abbreviations are defined as follows: 1.001 = compound No.1.001 DFZ = difenoconazole CPL = Cyprodinil Solution of Solution ofDFZ + CPL + expected 1.001 (1:2) observed % action ppm ppm ppm activity(colby) B26.1: Altnernaria solani 0.0016 57 0.0001 0.0003 0 0.00160.0001 0.0003 67 57 B26.2: Fusarium culmorum 0.0250 29 0.0021 0.0042 40.0250 0.0021 0.0042 47 32

TABLE B27 The abbreviations are defined as follows: 1.001 = compound No.1.001 DFZ = difenoconazole FLN = Fluazinam Solution of Solution DFZ +FLN expected of 1.001 (1:3) observed % action ppm ppm ppm activity(colby) B27.1: Fusarium culmorum 0.0250 27 0.0500 49 0.0016 0.0047 60.0031 0.0094 4 0.0250 0.0016 0.0047 41 32 0.0500 0.0031 0.0094 57 51B27.2: Monographella nivalis 0.0500 6 0.1000 27 0.2000 87 0.0500 0.15000 0.0500 0.0500 0.1500 78 6 0.1000 0.0500 0.1500 83 27 0.2000 0.05000.1500 97 87 B27.3: Botrytis cinerea 0.0016 49 0.0031 57 0.0063 630.0125 89 0.0004 0.0012 3 0.0016 0.0047 2 0.0031 0.0094 2 0.0063 0.01885 0.0125 0.0375 6 0.0016 0.0016 0.0047 74 50 0.0031 0.0031 0.0094 84 580.0063 0.0004 0.0012 74 65 0.0063 0.0031 0.0094 85 64 0.0063 0.00630.0188 100 65 0.0125 0.0063 0.0188 99 89 0.0125 0.0125 0.0375 100 89

TABLE B28 The abbreviations are defined as follows: 1.001 = compound No.1.001 AZ = azoxystrobin PTC = Prothioconazole Solution Solution of AZO +PTC expected of 1.001 (1:1) observed % action ppm ppm ppm activity(colby) B28.1: Gäumannomyces graminis 0.0031 0 0.0125 0 0.0250 0 0.05000 0.1000 0 0.2000 0 0.0063 0.0063 17 0.0250 0.0250 60 0.0500 0.0500 660.1000 0.1000 66 0.1000 0.1000 66 0.0031 0.0063 0.0063 40 17 0.01250.0250 0.0250 67 60 0.0250 0.0063 0.0063 41 17 0.0250 0.0500 0.0500 7666 0.0500 0.1000 0.1000 77 66 0.1000 0.0250 0.0250 71 60 0.1000 0.10000.1000 75 66 0.2000 0.1000 0.1000 78 66 B28.2: Alternaria solani 0.001624 0.0002 0.0002 5 0.0016 0.0016 6 0.0016 0.0002 0.0002 40 28 0.00160.0016 0.0016 44 29 B28.3: Fusarium culmorum 0.0500 55 0.1000 56 0.10000.1000 55 0.0500 0.1000 0.1000 100 80 0.1000 0.1000 0.1000 97 80 B28.4:Monographella nivalis 0.0016 0 0.0031 2 0.0125 2 0.0500 6 0.0031 0.003118 0.0063 0.0063 63 0.0016 0.0031 0.0031 45 18 0.0031 0.0063 0.0063 9364 0.0125 0.0063 0.0063 73 64 0.0500 0.0063 0.0063 95 65

TABLE B29 The abbreviations are defined as follows: 1.001 = compound No.1.001 AZ = azoxystrobin TCZ = Tebuconazole Solution of Solution AZO +TCZ expected of 1.001 (1:1) observed % action ppm ppm ppm activity(colby) B29.1: Gäumannomyces graminis 0.0250 2 0.0500 0 0.1000 0 0.20000 0.0031 0.0031 4 0.0250 0.0250 44 0.0500 0.0500 69 0.0250 0.0031 0.003141 6 0.0250 0.0250 0.0250 58 45 0.0500 0.0250 0.0250 66 44 0.0500 0.05000.0500 79 69 0.1000 0.0500 0.0500 78 69 0.2000 0.0250 0.0250 53 44B29.2: Monographella nivalis 0.0250 0 0.0063 0.0063 62 0.0250 0.00630.0063 73 62 B29.3: Septoria tritici 0.0008 17 0.0016 40 0.0031 880.0016 0.0016 0 0.0031 0.0031 12 0.0063 0.0063 3 0.0008 0.0016 0.0016 2217 0.0016 0.0031 0.0031 68 47 0.0031 0.0063 0.0063 95 89

TABLE B30 The abbreviations are defined as follows: 1.001 = compound No.1.001 AZ = azoxystrobin PYS = Pyraclostrobin Solution of Solution AZO +PYS expected of 1.001 (2:1) observed % action ppm ppm ppm activity(colby) B30.1: Gäumannomyces graminis 0.0031 7 0.0125 0 0.0250 0 0.05001 0.1000 4 0.2000 0 0.0084 0.0041 40 0.0168 0.0083 51 0.0335 0.0165 550.0670 0.0330 53 0.1340 0.0660 53 0.1340 0.0660 62 0.0031 0.0084 0.004152 45 0.0125 0.0168 0.0083 60 51 0.0125 0.0335 0.0165 66 55 0.02500.0084 0.0041 53 40 0.0250 0.0335 0.0165 72 55 0.0250 0.0670 0.0330 8053 0.0500 0.0335 0.0165 64 56 0.0500 0.0670 0.0330 66 54 0.1000 0.03350.0165 72 57 0.1000 0.0670 0.0330 69 55 0.1000 0.1340 0.0660 75 630.2000 0.0335 0.0165 64 55 0.2000 0.0670 0.0330 61 53 0.2000 0.13400.0660 68 62 B30.2: Alternaria solani 0.0016 31 0.0021 0.0010 11 0.00420.0021 7 0.0016 0.0021 0.0010 58 38 0.0016 0.0042 0.0021 58 36 B30.3:Fusarium culmorum 0.0250 28 0.0500 55 0.1000 56 0.0670 0.0330 0 0.13400.0660 8 0.0250 0.0670 0.0330 43 28 0.0500 0.0670 0.0330 61 55 0.05000.1340 0.0660 66 58 0.1000 0.1340 0.0660 69 60 B30.4: Monographellanivalis 0.0016 0 0.0031 0 0.0021 0.0010 31 0.0042 0.0021 52 0.00160.0021 0.0010 61 31 0.0016 0.0042 0.0021 61 52 0.0031 0.0042 0.0021 8252

TABLE B31 The abbreviations are defined as follows: 1.001 = compound No.1.001 AZ = azoxystrobin TFS = Trifloxystrobin Solution Solution of AZO +TFS expected of 1.001 (2:1) observed % action ppm ppm ppm activity(colby) B31.1: Gäumannomyces graminis 0.0063 0 0.0125 0 0.0250 4 0.05000 0.2000 3 0.0084 0.0041 41 0.0168 0.0083 61 0.0335 0.0165 44 0.00630.0084 0.0041 51 41 0.0063 0.0168 0.0083 67 61 0.0125 0.0084 0.0041 5641 0.0125 0.0168 0.0083 69 61 0.0125 0.0335 0.0165 76 44 0.0250 0.03350.0165 75 46 0.0500 0.0335 0.0165 53 44 0.2000 0.0335 0.0165 72 46B31.2: Alternaria solani 0.0008 1 0.0003 0.0001 0 0.0005 0.0003 5 0.00100.0005 0 0.0008 0.0003 0.0001 39 1 0.0008 0.0005 0.0003 34 5 0.00080.0010 0.0005 42 1 B31.3: Fusarium culmorum 0.0125 11 0.0250 29 0.050052 0.1000 52 0.2000 59 0.0335 0.0165 11 0.0670 0.0330 7 0.1340 0.0660 70.0125 0.0335 0.0165 42 20 0.0250 0.0335 0.0165 58 36 0.0250 0.06700.0330 73 34 0.0500 0.0335 0.0165 64 57 0.0500 0.0670 0.0330 74 560.0500 0.1340 0.0660 77 56 0.1000 0.0670 0.0330 72 55 0.1000 0.13400.0660 78 55 0.2000 0.0670 0.0330 71 62 0.2000 0.1340 0.0660 75 62B31.4: Monographella nivalis 0.0004 0 0.0008 0 0.0010 0.0005 37 0.00040.0010 0.0005 64 37 0.0008 0.0010 0.0005 55 37 B31.5: Septoria tritici0.0016 44 0.0042 0.0021 65 0.0016 0.0042 0.0021 95 80 B31.6: Botrytiscinerea 0.0008 29 0.0016 51 0.0021 0.0010 18 0.0042 0.0021 34 0.00080.0021 0.0010 65 42 0.0016 0.0042 0.0021 76 68

TABLE B32 The abbreviations are defined as follows: 1.001 = compound No.1.001 AZ = azoxystrobin FDL = Fludioxonil Solution Solution of AZO + FDLexpected of 1.001 (1:2) observed % action ppm ppm ppm activity (colby)B32.1: Gäumannomyces graminis 0.0063 10 0.0125 1 0.0250 6 0.0500 00.1000 0 0.2000 0 0.0041 0.0084 11 0.0083 0.0168 34 0.0165 0.0335 550.0660 0.1340 63 0.0063 0.0041 0.0084 35 20 0.0125 0.0041 0.0084 38 110.0125 0.0083 0.0168 63 35 0.0250 0.0083 0.0168 48 38 0.0500 0.06600.1340 70 63 0.1000 0.0083 0.0168 49 34 0.1000 0.0165 0.0335 63 550.2000 0.0165 0.0335 66 55 B32.2: Alternaria solani 0.0016 38 0.0031 690.0003 0.0005 0 0.0005 0.0010 0 0.0010 0.0021 1 0.0021 0.0042 0 0.00160.0003 0.0005 69 38 0.0016 0.0005 0.0010 45 38 0.0016 0.0021 0.0042 7438 0.0031 0.0010 0.0021 77 69 B32.3: Fusarium culmorum 0.0250 24 0.050051 0.1000 55 0.2000 57 0.0330 0.0670 0 0.0660 0.1340 0 0.0660 0.1340 100.0250 0.0330 0.0670 47 24 0.0500 0.0330 0.0670 84 51 0.0500 0.06600.1340 83 56 0.1000 0.0330 0.0670 71 55 0.1000 0.0660 0.1340 95 590.2000 0.0330 0.0670 65 57 0.2000 0.0660 0.1340 91 61 B32.4: Rhizoctoniasolani 0.0500 11 0.1000 10 0.0330 0.0670 0 0.0660 0.1340 20 0.05000.0330 0.0670 58 11 0.0500 0.0660 0.1340 76 29 0.1000 0.0660 0.1340 9428 B32.5: Botrytis cinerea 0.0031 63 0.0063 85 0.0041 0.0084 10 0.00830.0168 36 0.0031 0.0041 0.0084 79 66 0.0063 0.0083 0.0168 100 90

TABLE B33 The abbreviations are defined as follows: 1.001 = compound No.1.001 AZ = azoxystrobin CPL = Cyprodinil Solution Solution of AZO + CPLexpected of 1.001 (1:2) observed % action ppm ppm ppm activity (colby)B33.1: Gäumannomyces graminis 0.0125 0 0.0250 0 0.0500 0 0.1000 0 0.20002 0.0083 0.0168 50 0.0165 0.0335 43 0.0330 0.0670 56 0.0125 0.00830.0168 65 50 0.0125 0.0165 0.0335 81 43 0.0250 0.0165 0.0335 65 430.0250 0.0330 0.0670 83 56 0.0500 0.0330 0.0670 73 56 0.1000 0.01650.0335 61 43 0.2000 0.0330 0.0670 64 57 B33.2: Alternaria solani 0.00089 0.0016 44 0.0001 0.0003 0 0.0003 0.0005 3 0.0008 0.0001 0.0003 26 90.0008 0.0003 0.0005 35 11 0.0016 0.0003 0.0005 53 45 B33.3:Monographella nivalis 0.0031 0 0.0063 0 0.0125 0 0.0041 0.0084 29 0.00310.0041 0.0084 61 29 0.0063 0.0041 0.0084 58 29 0.0125 0.0041 0.0084 4329

TABLE B34 The abbreviations are defined as follows: 1.001 = compound No.1.001 AZ = azoxystrobin FLN = Fluazinam Solution Solution of AZO + FLNexpected of 1.001 (1:3) observed % action ppm ppm ppm activity (colby)B34.1: Gäumannomyces graminis 0.0063 0 0.0125 0 0.0250 4 0.0500 0 0.20000 0.0063 0.0188 20 0.0125 0.0375 48 0.0250 0.0750 57 0.0063 0.00630.0188 55 20 0.0125 0.0063 0.0188 50 20 0.0125 0.0125 0.0375 71 480.0250 0.0250 0.0750 77 59 0.0500 0.0250 0.0750 74 57 0.2000 0.02500.0750 81 57 B34.2: Monographella nivalis 0.0031 0 0.0063 0 0.0125 00.0250 0 0.0031 0.0094 17 0.0031 0.0031 0.0094 98 17 0.0063 0.00310.0094 71 17 0.0125 0.0031 0.0094 51 17 0.0250 0.0031 0.0094 42 17B34.3: Septoria tritici 0.0008 36 0.0016 53 0.0008 0.0023 2 0.00160.0047 6 0.0008 0.0008 0.0023 54 37 0.0016 0.0016 0.0047 75 56 B34.4:Botrytis cinerea 0.0031 73 0.0031 0.0094 2 0.0031 0.0031 0.0094 90 74

TABLE B35 The abbreviations are defined as follows: 1.001 = compound No.1.001 PTC = Prothioconazole TCZ = Tebuconazole Solution Solution ofPTC + TCZ expected of 1.001 1:1 observed % action ppm ppm ppm activity(colby) B35.1: Gäumannomyces graminis 0.0250 7 0.0500 9 0.1000 17 0.05000.0500 0 0.1000 0.1000 53 0.0250 0.0500 0.0500 57 7 0.0500 0.1000 0.100088 58 0.1000 0.1000 0.1000 100 61 B35.2: Alternaria solani 0.0016 70.0063 75 0.0031 0.0031 13 0.0063 0.0063 6 0.0016 0.0031 0.0031 44 190.0063 0.0031 0.0031 87 78 0.0063 0.0063 0.0063 89 76 B35.3: Fusariumculmorum 0.0125 7 0.0250 46 0.0250 0.0250 31 0.0500 0.0500 40 0.01250.0250 0.0250 59 36 0.0250 0.0500 0.0500 100 67 B35.4: Monographellanivalis 0.0125 0 0.0250 0.0250 0 0.0125 0.0250 0.0250 91 0

TABLE B36 Solution of PTC + PYS observed expected Solution of 1.001 2:1% action ppm ppm ppm activity (colby) B36.1: Gäumannomyces graminis0.0500 7 0.1340 0.0660 41 0.0500 0.1340 0.0660 100 46 B36.2: Fusariumculmorum 0.0250 29 0.0042 0.0021 1 0.0250 0.0042 0.0021 46 30 B36.3:Monographella nivalis 0.0031 2 0.0063 0 0.0084 0.0041 30 0.0168 0.008390 0.0031 0.0084 0.0041 51 32 0.0063 0.0084 0.0041 39 30 0.0063 0.01680.0083 99 90 The abbreviations are defined as follows: 1.001 = compoundNo. 1.001 PTC = Prothioconazole PYS = Pyraclostrobin

TABLE B37 Solution of PTC + TFS observed expected Solution of 1.001 2:1% action ppm ppm ppm activity (colby) B37.1 Fusarium culmorum 0.0125 100.0250 27 0.0335 0.0165 16 0.0670 0.0330 41 0.0125 0.0335 0.0165 39 240.0250 0.0670 0.0330 96 57 B37.2: Monographella nivalis 0.0004 0 0.00050.0003 81 0.0004 0.0005 0.0003 95 81 The abbreviations are defined asfollows: 1.001 = compound No. 1.001 PTC = Prothioconazole TFS =Trifloxystrobin

TABLE B38 Solution of PTC + FDL observed expected Solution of 1.001 1:2% action ppm ppm ppm activity (colby) B38.1: Alternaria solani 0.0008 40.0016 14 0.0031 46 0.0005 0.0010 0 0.0010 0.0021 0 0.0021 0.0042 60.0008 0.0005 0.0010 27 4 0.0008 0.0010 0.0021 25 4 0.0016 0.0021 0.004242 18 0.0031 0.0021 0.0042 75 49 B38.2: Fusarium culmorum 0.0125 90.0250 28 0.0500 52 0.0165 0.0335 9 0.0330 0.0670 12 0.0125 0.01650.0335 34 17 0.0250 0.0165 0.0335 44 35 0.0250 0.0330 0.0670 62 370.0500 0.0330 0.0670 64 57 B38.3: Botrytis cinerea 0.0016 21 0.0031 420.0063 64 0.0021 0.0042 4 0.0041 0.0084 1 0.0083 0.0168 25 0.0016 0.00210.0042 29 24 0.0031 0.0041 0.0084 69 43 0.0063 0.0041 0.0084 77 640.0063 0.0083 0.0168 96 73 The abbreviations are defined as follows:1.001 = compound No. 1.001 PTC = Prothioconazole FDL = Fludioxonil

TABLE B39 Solution of PTC + CPL observed expected Solution of 1.001 1:2% action ppm ppm ppm activity (colby) B39.1: Monographella nivalis0.0031 0 0.0063 0 0.0125 2 0.0041 0.0084 18 0.0083 0.0168 68 0.00310.0041 0.0084 45 18 0.0063 0.0041 0.0084 39 18 0.0063 0.0083 0.0168 8668 0.0125 0.0083 0.0168 81 68 B39.2: Septoria tritici 0.0016 59 0.00010.0003 3 0.0016 0.0001 0.0003 78 60 B39.3: Botrytis cinerea 0.0031 390.0063 64 0.0003 0.0005 0 0.0010 0.0021 0 0.0021 0.0042 0 0.0041 0.00840 0.0031 0.0003 0.0005 54 39 0.0031 0.0010 0.0021 46 39 0.0031 0.00410.0084 68 39 0.0063 0.0021 0.0042 76 64 0.0063 0.0041 0.0084 73 64 Theabbreviations are defined as follows: 1.001 = compound No. 1.001 PTC =Prothioconazole CPL = Cyprodinil

TABLE B40 Solution of PTC + FLN observed expected Solution of 1.001 1:3% action ppm ppm ppm activity (colby) B40.1: Alternaria solani 0.0016 250.0031 50 0.0016 0.0047 5 0.0031 0.0094 5 0.0016 0.0016 0.0047 45 290.0031 0.0016 0.0047 62 53 0.0031 0.0031 0.0094 64 53 B40.2:Monographella nivalis 0.0031 2 0.0063 0 0.0125 2 0.0250 3 0.0500 00.0031 0.0094 13 0.0063 0.0188 38 0.0031 0.0031 0.0094 28 14 0.00630.0063 0.0188 98 38 0.0125 0.0063 0.0188 84 39 0.0250 0.0063 0.0188 6140 0.0500 0.0063 0.0188 66 38 B40.3: Septoria tritici 0.0016 60 0.003189 0.0001 0.0003 0 0.0031 0.0094 0 0.0016 0.0001 0.0003 70 60 0.00310.0031 0.0094 99 89 B40.4: Botrytis cinerea 0.0016 26 0.0031 48 0.006366 0.0125 88 0.0016 0.0047 6 0.0031 0.0094 9 0.0063 0.0188 20 0.00160.0016 0.0047 60 30 0.0031 0.0016 0.0047 57 51 0.0031 0.0031 0.0094 9652 0.0063 0.0031 0.0094 91 69 0.0063 0.0063 0.0188 100 73 0.0125 0.00630.0188 99 90 The abbreviations are defined as follows: 1.001 = compoundNo. 1.001 PTC = Prothioconazole FLN = Fluazinam

TABLE B41 Solution of TCZ + PYS observed expected Solution of 1.001 2:1% action ppm ppm ppm activity (colby) B41.1: Alternaria solani 0.0016 490.0031 81 0.0042 0.0021 5 0.0084 0.0041 17 0.0016 0.0042 0.0021 78 520.0031 0.0084 0.0041 94 84 B41.2: Monographella nivalis 0.0031 10 0.006314 0.0125 4 0.0250 23 0.0500 40 0.1000 67 0.0042 0.0021 23 0.0084 0.004110 0.0168 0.0083 32 0.0031 0.0042 0.0021 48 31 0.0031 0.0084 0.0041 6419 0.0063 0.0084 0.0041 100 22 0.0063 0.0168 0.0083 90 42 0.0125 0.01680.0083 100 35 0.0250 0.0168 0.0083 66 48 0.0500 0.0084 0.0041 51 460.0500 0.0168 0.0083 77 59 0.1000 0.0168 0.0083 96 78 B41.3: Botrytiscinerea 0.0008 33 0.0016 54 0.0031 73 0.0063 88 0.0005 0.0003 3 0.00210.0010 0 0.0042 0.0021 0 0.0084 0.0041 7 0.0008 0.0021 0.0010 52 330.0016 0.0021 0.0010 78 54 0.0016 0.0042 0.0021 96 54 0.0031 0.00050.0003 81 74 0.0031 0.0021 0.0010 80 73 0.0031 0.0042 0.0021 98 730.0031 0.0084 0.0041 100 75 0.0063 0.0042 0.0021 97 88 0.0063 0.00840.0041 99 89 The abbreviations as follows: are defined 1.001 = compoundNo. 1.001 TCZ = Tebuconazole PYS = Pyraclostrobin

TABLE B42 Solution of TCZ + TFS observed expected Solution of 1.001 2:1% action ppm ppm ppm activity (colby) B42.1: Alternaria solani 0.0004 100.0008 30 0.0016 54 0.0010 0.0005 10 0.0021 0.0010 17 0.0042 0.0021 90.0004 0.0010 0.0005 30 19 0.0008 0.0021 0.0010 44 42 0.0016 0.00420.0021 74 58 B42.2: Fusarium culmorum 0.0125 16 0.0250 34 0.0500 540.1000 58 0.2000 59 0.0042 0.0021 1 0.0168 0.0083 1 0.0335 0.0165 20.0670 0.0330 6 0.1340 0.0660 6 0.1340 0.0660 8 0.0125 0.0168 0.0083 4217 0.0125 0.0335 0.0165 58 18 0.0250 0.0042 0.0021 51 35 0.0250 0.01680.0083 51 35 0.0250 0.0335 0.0165 66 36 0.0250 0.0670 0.0330 71 390.0500 0.0168 0.0083 60 54 0.0500 0.0335 0.0165 69 55 0.0500 0.06700.0330 78 57 0.0500 0.1340 0.0660 75 57 0.1000 0.0335 0.0165 72 590.1000 0.0670 0.0330 78 61 0.1000 0.1340 0.0660 80 61 0.2000 0.03350.0165 75 60 0.2000 0.0670 0.0330 76 62 0.2000 0.1340 0.0660 83 63B42.3: Rhizoctonia solani 0.0250 0 0.0500 0 0.1000 15 0.0670 0.0330 350.1340 0.0660 13 0.0250 0.0670 0.0330 51 35 0.0500 0.1340 0.0660 68 130.1000 0.1340 0.0660 52 26 B42.4: Septoria tritici 0.0004 9 0.0008 240.0016 64 0.0010 0.0005 10 0.0021 0.0010 34 0.0004 0.0010 0.0005 27 170.0008 0.0010 0.0005 65 32 0.0008 0.0021 0.0010 80 50 0.0016 0.00100.0005 88 67 0.0016 0.0021 0.0010 86 76 B42.5: Botrytis cinerea 0.000824 0.0016 45 0.0031 76 0.0021 0.0010 15 0.0042 0.0021 32 0.0008 0.00210.0010 72 35 0.0016 0.0021 0.0010 88 53 0.0016 0.0042 0.0021 98 620.0031 0.0021 0.0010 89 79 0.0031 0.0042 0.0021 99 83 The abbreviationsare defined as follows: 1.001 = compound No. 1.001 TCZ = TebuconazoleTFS = Trifloxystrobin

TABLE B43 Solution of TCZ + FDL observed expected Solution of 1.001 1:2% action ppm ppm ppm activity (colby) B43.1: Alternaria solani 0.0016 450.0001 0.0003 0 0.0021 0.0042 0 0.0016 0.0001 0.0003 54 45 0.0016 0.00210.0042 78 45 B43.2: Fusarium culmorum 0.0250 34 0.0500 55 0.1000 550.2000 61 0.0330 0.0670 1 0.0660 0.1340 1 0.0660 0.1340 25 0.0250 0.03300.0670 56 34 0.0500 0.0330 0.0670 89 56 0.0500 0.0660 0.1340 100 670.1000 0.0330 0.0670 81 56 0.1000 0.0660 0.1340 97 66 0.2000 0.03300.0670 76 61 0.2000 0.0660 0.1340 98 71 B43.3: Monographella nivalis0.0063 1 0.0125 4 0.0250 14 0.0500 11 0.0041 0.0084 24 0.0083 0.0168 700.0063 0.0083 0.0168 95 70 0.0125 0.0083 0.0168 98 71 0.0250 0.00410.0084 55 35 0.0250 0.0083 0.0168 100 74 0.0500 0.0041 0.0084 59 33B43.4: Botrytis cinerea 0.0008 36 0.0016 51 0.0031 80 0.0005 0.0010 00.0010 0.0021 12 0.0021 0.0042 37 0.0041 0.0084 22 0.0008 0.0005 0.001042 36 0.0016 0.0021 0.0042 91 69 0.0031 0.0010 0.0021 94 82 0.00310.0041 0.0084 100 84 The abbreviations are defined as follows: 1.001 =compound No. 1.001 TCZ = Tebuconazole FDL = Fludioxonil

TABLE B44 Solution of TCZ + CPL observed expected Solution of 1.001 1:2% action ppm ppm ppm activity (colby) B44.1: Alternaria solani 0.0016 350.0001 0.0003 8 0.0003 0.0005 0 0.0005 0.0010 0 0.0010 0.0021 4 0.00210.0042 5 0.0016 0.0001 0.0003 57 40 0.0016 0.0003 0.0005 52 35 0.00160.0005 0.0010 47 35 0.0016 0.0010 0.0021 64 38 0.0016 0.0021 0.0042 5239 B44.2: Monographella nivalis 0.0016 4 0.0031 0 0.0063 3 0.0021 0.004210 0.0041 0.0084 52 0.0016 0.0021 0.0042 35 14 0.0031 0.0041 0.0084 9752 0.0063 0.0041 0.0084 91 53 The abbreviations are defined as follows:1.001 = compound No. 1.001 TCZ = Tebuconazole CPL = Cyprodinil

TABLE B45 Solution of TCZ + FLN observed expected Solution of 1.001 1:3% action ppm ppm ppm activity (colby) B45.1: Alternaria solani 0.0008 100.0016 40 0.0031 76 0.0001 0.0003 0 0.0002 0.0006 0 0.0004 0.0012 00.0008 0.0023 5 0.0016 0.0047 10 0.0031 0.0094 22 0.0008 0.0004 0.001227 10 0.0016 0.0001 0.0003 50 40 0.0016 0.0008 0.0023 46 43 0.00160.0016 0.0047 66 45 0.0031 0.0002 0.0006 88 76 0.0031 0.0016 0.0047 9078 0.0031 0.0031 0.0094 92 81 B45.2: Monographella nivalis 0.0016 20.0031 0 0.0063 5 0.0125 5 0.0250 6 0.0500 9 0.0016 0.0047 0 0.00310.0094 45 0.0016 0.0016 0.0047 31 2 0.0031 0.0031 0.0094 90 45 0.00630.0031 0.0094 73 48 0.0125 0.0031 0.0094 79 48 0.0250 0.0016 0.0047 29 60.0500 0.0031 0.0094 84 50 B45.3: Botrytis cinerea 0.0008 36 0.0016 680.0031 86 0.0004 0.0012 3 0.0008 0.0023 8 0.0016 0.0047 6 0.0031 0.009410 0.0008 0.0004 0.0012 59 38 0.0008 0.0008 0.0023 85 41 0.0016 0.00080.0023 94 71 0.0016 0.0016 0.0047 99 70 0.0031 0.0016 0.0047 99 870.0031 0.0031 0.0094 100 88 The abbreviations are defined as follows:1.001 = compound No. 1.001 TCZ = Tebuconazole FLN = Fluazinam

TABLE B46 Solution of PYS + TFS observed expected Solution of 1.001 1:1% action ppm ppm ppm activity (colby) B46.1: Alternaria solani 0.0016 530.0031 73 0.0002 0.0002 0 0.0008 0.0008 0 0.0031 0.0031 13 0.0063 0.006320 0.0016 0.0002 0.0002 65 53 0.0016 0.0031 0.0031 67 59 0.0031 0.00080.0008 80 73 0.0031 0.0031 0.0031 86 76 0.0031 0.0063 0.0063 89 78B46.2: Monographella nivalis 0.0016 1 0.0031 2 0.0063 0 0.0250 7 0.00310.0031 25 0.0063 0.0063 66 0.0016 0.0031 0.0031 37 26 0.0031 0.00630.0063 98 67 0.0063 0.0031 0.0031 55 25 0.0063 0.0063 0.0063 76 660.0250 0.0063 0.0063 100 69 B46.3: Septoria tritici 0.0016 53 0.00040.0004 0 0.0016 0.0016 1 0.0031 0.0031 1 0.0016 0.0004 0.0004 61 530.0016 0.0016 0.0016 60 54 0.0016 0.0031 0.0031 66 54 B46.4: Botrytiscinerea 0.0016 43 0.0002 0.0002 3 0.0008 0.0008 0 0.0016 0.0002 0.000252 45 0.0016 0.0008 0.0008 51 43 The abbreviations are defined asfollows: 1.001 = compound No. 1.001 PYS = Pyraclostrobin TFS =Trifloxystrobin

TABLE B47 Solution of PYS + FDL observed expected Solution of 1.001 1:4% action ppm ppm ppm activity (colby) B47.1: Alternia solani 0.0016 530.0013 0.0050 2 0.0016 0.0013 0.0050 71 54 B47.2: Septoria tritici0.0008 15 0.0016 53 0.0006 0.0025 14 0.0013 0.0050 39 0.0008 0.00060.0025 48 26 0.0016 0.0013 0.0050 90 71 B47.3: Botrytis cinerea 0.001642 0.0031 68 0.0013 0.0050 16 0.0025 0.0100 38 0.0016 0.0013 0.0050 8851 0.0031 0.0013 0.0050 93 73 0.0031 0.0025 0.0100 99 80 Theabbreviations are defined as follows: 1.001 = compound No. 1.001 PYS =Pyraclostrobin FDL = Fludioxonil

TABLE B48 Solution of PYS + CPL observed expected Solution of 1.001 1:4% action ppm ppm ppm activity (colby) B48.1: Alternaria solani 0.0008 240.0016 46 0.0001 0.0003 8 0.0003 0.0013 1 0.0006 0.0025 2 0.0013 0.00502 0.0008 0.0006 0.0025 34 26 0.0016 0.0001 0.0003 59 50 0.0016 0.00030.0013 55 47 0.0016 0.0006 0.0025 59 48 0.0016 0.0013 0.0050 70 48B48.2: Fusarium culmorum 0.0125 10 0.0250 32 0.0500 59 0.1000 56 0.200060 0.0100 0.0400 12 0.0200 0.0800 8 0.0400 0.1600 8 0.0400 0.1600 350.0125 0.0100 0.0400 36 20 0.0250 0.0100 0.0400 46 40 0.0250 0.02000.0800 56 37 0.0500 0.0400 0.1600 100 73 0.1000 0.0200 0.0800 73 600.1000 0.0400 0.1600 98 71 0.2000 0.0400 0.1600 98 74 B48.3:Monographella nivalis 0.0250 15 0.0500 21 0.0050 0.0200 0 0.0200 0.08000 0.0400 0.1600 46 0.0250 0.0200 0.0800 48 15 0.0500 0.0050 0.0200 58 210.0500 0.0400 0.1600 85 57 B48.4: Rhizoctonia solani 0.0500 0 0.2000 00.0400 0.1600 16 0.0400 0.1600 61 0.0500 0.0400 0.1600 76 61 0.20000.0400 0.1600 72 61 B48.5: Septoria tritici 0.0016 58 0.0013 0.0050 00.0016 0.0013 0.0050 67 58 B48.6: Botrytis cinerea 0.0008 30 0.0016 590.0031 76 0.0002 0.0006 3 0.0006 0.0025 7 0.0013 0.0050 0 0.0025 0.010021 0.0008 0.0002 0.0006 44 32 0.0008 0.0006 0.0025 41 35 0.0016 0.00130.0050 91 59 0.0031 0.0006 0.0025 91 78 0.0031 0.0013 0.0050 85 760.0031 0.0025 0.0100 99 81 The abbreviations are defined as follows:1.001 = compound No. 1.001 PYS = Pyraclostrobin CPL = Cyprodinil

TABLE B49 Solution of PYS + FLN observed expected Solution of 1.001 1:6% action ppm ppm ppm activity (colby) B49.1: Monographella nivalis0.0031 6 0.0018 0.0107 13 0.0031 0.0018 0.0107 86 18 B49.2: Botrytiscinerea 0.0016 48 0.0002 0.0013 0 0.0009 0.0054 0 0.0016 0.0002 0.001353 48 0.0016 0.0009 0.0054 56 48 The abbreviations are defined asfollows: 1.001 = compound No. 1.001 PYS = Pyraclostrobin FLN = Fluazinam

TABLE B50 Solution of TFS + FDL observed expected Solution of 1.001 1:4% action ppm ppm ppm activity (colby) B50.1: Fusarium culmorum 0.0125 110.0250 33 0.0500 56 0.1000 59 0.2000 65 0.0050 0.0200 2 0.0100 0.0400 200.0200 0.0800 29 0.0125 0.0050 0.0200 51 12 0.0125 0.0100 0.0400 50 280.0250 0.0050 0.0200 50 34 0.0250 0.0100 0.0400 62 46 0.0250 0.02000.0800 100 53 0.0500 0.0200 0.0800 93 69 0.1000 0.0200 0.0800 88 710.2000 0.0200 0.0800 93 76 B50.2: Monographella nivalis 0.0004 0 0.00083 0.0003 0.0013 44 0.0004 0.0003 0.0013 67 44 0.0008 0.0003 0.0013 73 46B50.3: Rhizoctonia solani 0.1000 0 0.2000 0 0.0400 0.1600 30 0.04000.1600 65 0.1000 0.0400 0.1600 99 65 0.2000 0.0400 0.1600 96 65 B50.4:Septoria tritici 0.0008 27 0.0016 56 0.0006 0.0025 10 0.0013 0.0050 210.0008 0.0006 0.0025 47 34 0.0016 0.0006 0.0025 78 60 0.0016 0.00130.0050 73 65 B50.5: Botrytis cinerea 0.0008 9 0.0016 26 0.0031 49 0.00060.0025 6 0.0013 0.0050 33 0.0025 0.0100 37 0.0008 0.0006 0.0025 22 140.0016 0.0013 0.0050 78 50 0.0031 0.0025 0.0100 89 68 The abbreviationsare defined as follows: 1.001 = compound No. 1.001 TFS = TrifloxystrobinFDL = Fludioxonil

TABLE B51 Solution of TFS + CPL observed expected Solution of 1.001 1:4% action ppm ppm ppm activity (colby) B51.1: Fusarium culmorum 0.0250 290.0500 54 0.1000 57 0.2000 58 0.0100 0.0400 7 0.0200 0.0800 6 0.04000.1600 6 0.0400 0.1600 8 0.0250 0.0100 0.0400 56 34 0.0250 0.0200 0.080070 33 0.0500 0.0100 0.0400 64 57 0.0500 0.0200 0.0800 77 56 0.05000.0400 0.1600 80 58 0.1000 0.0100 0.0400 67 60 0.1000 0.0200 0.0800 7760 0.1000 0.0400 0.1600 84 61 0.2000 0.0200 0.0800 73 60 0.2000 0.04000.1600 83 62 B51.2: Monographella nivalis 0.0004 2 0.0008 0 0.0016 00.0031 2 0.0125 0 0.0003 0.0013 46 0.0006 0.0025 88 0.0004 0.0003 0.001398 48 0.0008 0.0003 0.0013 93 46 0.0008 0.0006 0.0025 98 88 0.00160.0006 0.0025 98 88 0.0031 0.0006 0.0025 97 88 0.0125 0.0006 0.0025 9788 B51.3: Septoria tritici 0.0008 18 0.0016 47 0.0006 0.0025 10 0.00130.0050 25 0.0008 0.0006 0.0025 34 26 0.0016 0.0013 0.0050 78 60 Theabbreviations are defined as follows: 1.001 = compound No. 1.001 TFS =Trifloxystrobin CPL = Cyprodinil

TABLE B52 Solution of TFS + FLN observed expected Solution of 1.001 1:6% action ppm ppm ppm activity (colby) B52.1: Alternaria solani 0.0016 210.0031 57 0.0009 0.0054 5 0.0016 0.0009 0.0054 48 25 0.0031 0.00090.0054 82 59 B52.2: Fusarium culmorum 0.0125 6 0.0250 26 0.0072 0.042823 0.0143 0.0857 30 0.0125 0.0072 0.0428 40 28 0.0250 0.0143 0.0857 5848 B52.3: Monographella nivalis 0.0004 3 0.0063 2 0.0002 0.0013 380.0004 0.0002 0.0013 97 40 0.0063 0.0002 0.0013 85 39 B52.4: Botrytiscinerea 0.0016 29 0.0031 58 0.0063 74 0.0009 0.0054 18 0.0018 0.0107 760.0016 0.0009 0.0054 84 42 0.0031 0.0009 0.0054 91 65 0.0031 0.00180.0107 100 90 0.0063 0.0009 0.0054 88 79 The abbreviations are definedas follows: 1.001 = compound No. 1.001 TFS = Trifloxystrobin FLN =Fluazinam

TABLE B53 Solution of FDL + CPL observed expected Solution of 1.001(1:1) % action ppm ppm ppm activity (colby) B53.1: Fusarium culmorum0.0500 49 0.1000 59 0.2000 55 0.1000 0.1000 8 0.1000 0.1000 6 0.05000.1000 0.1000 81 51 0.1000 0.1000 0.1000 85 62 0.2000 0.1000 0.1000 8458 B53.2: Monographella nivalis 0.0063 0 0.0125 0 0.0125 0.0125 260.0063 0.0125 0.0125 67 26 0.0125 0.0125 0.0125 46 26 B53.3: Botrytiscinerea 0.0016 49 0.0031 71 0.0063 87 0.0031 0.0031 3 0.0063 0.0063 40.0125 0.0125 16 0.0016 0.0031 0.0031 61 50 0.0031 0.0063 0.0063 91 720.0063 0.0063 0.0063 97 87 0.0063 0.0125 0.0125 100 89 The abbreviationsare defined as follows: 1.001 = compound No. 1.001 FDL = Fludioxonil CPL= Cyprodinil

TABLE B54 Solution of FDL + FLN observed expected Solution of 1.001(2:3) % action ppm ppm ppm activity (colby) B54.1: Alternaria solani0.0008 42 0.0002 0.0002 3 0.0008 0.0002 0.0002 65 44 B54.2: Fusariumculmorum 0.0500 51 0.1000 55 0.2000 60 0.0400 0.0600 0 0.0800 0.1200 00.0800 0.1200 15 0.0500 0.0400 0.0600 64 51 0.0500 0.0800 0.1200 87 590.1000 0.0400 0.0600 61 55 0.1000 0.0800 0.1200 87 62 0.2000 0.04000.0600 75 60 0.2000 0.0800 0.1200 88 66 B54.3: Monographella nivalis0.0500 3 0.1000 22 0.0100 0.0150 5 0.0200 0.0300 0 0.0400 0.0600 10.0800 0.1200 67 0.0500 0.0400 0.0600 38 4 0.0500 0.0800 0.1200 100 680.1000 0.0100 0.0150 39 26 0.1000 0.0200 0.0300 46 22 0.1000 0.04000.0600 68 23 0.1000 0.0800 0.1200 94 74 B54.4: Botrytis cinerea 0.000834 0.0031 75 0.0063 89 0.0002 0.0002 9 0.0050 0.0075 4 0.0100 0.0150 80.0008 0.0002 0.0002 61 40 0.0031 0.0050 0.0075 89 76 0.0063 0.00500.0075 98 90 0.0063 0.0100 0.0150 100 90 The abbreviations are definedas follows: 1.001 = compound No. 1.001 FDL = Fludioxonil FLN = Fluazinam

TABLE B55 Solution of CPL + FLN observed expected Solution of 1.001(2:3) % action ppm ppm ppm activity (colby) B55.1: Alternaria solani0.0016 55 0.0002 0.0002 0 0.0003 0.0005 9 0.0016 0.0002 0.0002 69 550.0016 0.0003 0.0005 69 59 B55.2: Fusarium culmorum 0.0250 16 0.2000 510.0025 0.0038 0 0.0200 0.0300 0 0.0250 0.0025 0.0038 44 16 0.2000 0.02000.0300 60 51 B55.3: Monographella nivalis 0.1000 19 0.2000 79 0.01000.0150 2 0.0200 0.0300 28 0.1000 0.0100 0.0150 41 21 0.2000 0.02000.0300 90 85 B55.4: Septoria tritici 0.0016 63 0.0002 0.0002 5 0.00160.0002 0.0002 82 65 B55.5: Botrytis cinerea 0.0016 38 0.0031 53 0.006366 0.0125 83 0.0013 0.0019 1 0.0050 0.0075 4 0.0100 0.0150 4 0.00160.0013 0.0019 58 38 0.0031 0.0050 0.0075 76 55 0.0063 0.0050 0.0075 9467 0.0063 0.0100 0.0150 100 67 0.0125 0.0013 0.0019 94 84 0.0125 0.00500.0075 97 84 0.0125 0.0100 0.0150 100 84 The abbreviations are definedas follows: 1.001 = compound No. 1.001 CPL = Cyprodinil FLN = Fluazinam

What is claimed:
 1. A composition suitable for control of diseasescaused by phytopathogens comprising as component (A)3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide; and ascomponent (B) the compound of formula VII

and as component (C) a compound selected from the group consisting of:isopyrazam, difenoconazole, azoxystrobin, prothioconazole, tebuconazole,pyraclostrobin, trifloxystrobin, fludioxonil and cyprodinil.
 2. Thecomposition according to claim 1, wherein the weight ratio of (A) to(B+C) is from 2000:1 to 1:1000.
 3. The composition according to claim 1,wherein the weight ratio of (A) to (B+C) is from 4:1 to 1:4.
 4. Thecomposition according to claim 3, wherein the weight ratio of component(B) to component (C) is from 2:1 to 1:6.
 5. The composition according toclaim 1, selected from the group consisting of:3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide+thecompound of formula VII+isopyrazam;3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide+thecompound of formula VII+difenoconazole;3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide+thecompound of formula VII+azoxystrobin;3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide+thecompound of formula VII+prothioconazole;3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide+thecompound of formula VII+tebuconazole;3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide+thecompound of formula VII+pyraclostrobin;3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide+thecompound of formula VII+trifloxystrobin;3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide+thecompound of formula VII+fludioxonil; and3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide+thecompound of formula VII+cyprodinil.
 6. A method of controlling diseaseson useful plants or on propagation material thereof caused byphytopathogens, which comprises applying to the useful plants, the locusthereof or propagation material thereof a composition according toclaim
 1. 7. A method of protecting natural substances of plant and/oranimal origin, which have been taken from the natural life cycle, and/ortheir processed forms, which comprises applying to said naturalsubstances of plant and/or animal origin or their processed forms acombination of components (A), (B) and (C) according to claim 1.